Interaction Of Percocet And Tramadol

Updated

Multiple knee surgeries; bone spur on L heel secondary to limping on right leg for years; spondylolysthesis in back. Prescribed 1-2 Percocet(s) per night (5-325) to help sleep and Tramadol (50mgs, up to 4Xday). If my first 2 Trams haven't touched my pain (fell 2 days ago), would taking the remaining 2, plus the Percocets, have any kind of additive analgesic effect? Or would the stronger Perc render the Tram unnoticeable? Should mention I'm a pill horse: since childhood, I've had to take higher doses to get effects, w/ any drugs. I'm 5'11" and 185.

4 Replies

Earliest Newest Votes
1

Hello, Tristan! How are you?

No, you shouldn't take more than prescribed, per dose, or you may overdose. Both of these medications are considered opiate analgesics, so taking more at once could place you at risk.

They may also be habit forming and could cause side effects, such as nausea, dizziness, drowsiness, constipation and dry mouth.

Have you discussed the issue with your physician? They may need to prescribe something else for you.

Was this helpful? 0
2

Hi, Verwon! Than you for taking the time to consider my question. I'm not taking more than the prescribed dose of Percocet, but I am taking all of my day's allotment of Tramadol (total = 200 mgs) at once. Frankly, fewer than 3 at a time doesn't even touch it. I've taken in total, then, 200 mgs. of Tramadol and 2 of 5-325 Percocet on various occasions. I haven't had any negative reactions, aside from slight constipation. (Like a said: pill horse.) I'm just wondering if I'm wasting the Tramadol by taking it WITH the Percocet. By the evening, I'm such a hurtin' pup that 2 Percs don't do that much, but if the Tramadol would be better served taken at an earlier point, as a kind of booster or precursor (or later, for that matter) then I want to do so as efficiently as possible. Thank you again for your time!

Was this helpful? 0
3

Truly everyone is different, and there are genetic diagnostics that can be performed to see if you are a poor metabolizer of certain medications.

Via NIH.gov:

"Phase 1 Metabolism

The CYP3A4 enzyme is the primary metabolizer of fentanyl10 and oxycodone,11 although normally a small portion of oxycodone undergoes CYP2D6 metabolism to oxymorphone (Table 110-18). Tramadol undergoes both CYP3A4- and CYP2D6-mediated metabolism.16 Methadone is primarily metabolized by CYP3A4 and CYP2B6; CYP2C8, CYP2C19, CYP2D6, and CYP2C9 also contribute in varying degrees to its metabolism.19-23 The complex interplay of methadone with the CYP system, involving as many as 6 different enzymes, is accompanied by considerable interaction potential."

Also, more information here from the Consumer Health Information Corporation:

consumer-health.com/services/NewGeneticDiagnosticsHelpDoctorsPrescribetheRightMedicineforYou.php

Was this helpful? 0
4

I just took a (512) Percocet at 10:30pm Wednesday night; no meds today Thursday. So is it safe to take a Tramadol (Tv 58) now?

Was this helpful? 0

More Discussions:

instaflex Interaction with Declofenac, Tramadol and Tylenol

Is it okay to take Instaflex with Declofenac, Tramadol and Tylenol. I know white will bark has a substance similar to as...

3 REPLIES
Tramadol and Lortab drug interactions

Is there a danger or possible side effects of combining Tramadol (Qlodo) and Lortab? ## The main issue that occurs when ...

1 REPLY
remron and percocet interaction

I currently take nuvigil for my ADD amd the DR thinks I have shift worker disorder and possibly another sleep issue such...

1 REPLY
Tramadol and OTC Cold Medication Interactions

I’m currently on Tramadol 50mg for severe back issues. What over the counter cold medication is safe for me to tak...

1 REPLY
Tramadol with Ativan Drug Interactions & Side Effects

My doctor prescribed tramadol hcl 50 mg for pain in my joints, muscle and back. I also take 1mg Ativan twice a day. Shou...

1 REPLY
Interaction of Coumadin and Marijuana

Are there any interactions between Coumadin and Marijuana? ## i took coumadin and heperin after a blood clot that almost...

2 REPLIES
Interaction of forskolin and amlodipine

Please answer my question about taking Forskolin (weight loss supplement touted by Dr Oz) while on amlodipine, atenol an...

1 REPLY
interactions and effects of psych meds with your methadone

My question is I'm on 140 mg methadone liquid daily and have been and that dose for about 2 mos and on methadone all...

2 REPLIES
Interaction of adderral cymbalta and gabapentin

I am on cymbalta 60mg at night and 30mg in the morning along with 200mg of gabapentin 3x a day for fybromayalgia and mil...

2 REPLIES
Nitrofur-Macr and Methadone interactions

Hi. I've just been prescribed Nitrofur-Macr 100mg for a persistant bladder/Urinary tract infection which has been ma...

5 REPLIES