Grendis Trifusal

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Hi I would like to know more about the mode of actions,adverse effects,dosage,target groups of Grendis Triflusal.Thanks

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Grendis works in 3 ways, 1 just like aspirin, it inhibit thromboxane A2 thereby inhibiting aggregation or clumping of platelet, 2; just like cilostazol, it inhibit phosphodiesterase, thereby preserving cyclic AMP which is an anti aggregant also. I also stimulate human nitric oxide in human neutrofil thereby increasing it's antiinflammatory, vasodilatory and anti-aggregant effect. One good thing about triflusal is that, ublike aspirin, theres 50 % less incidence of bleeding due to preservation of prostacyclin, something that aspirin also inhbits. Prostacyclin is a powerful antia ggregant and has a protective vasodilatory effect. It's indicated for patients who had stroke, MI, and PAD and even aortocoronary bypass graft. It's not available in the US for 2 reasons, 1 for political, because since it's a European Drug, americans tend to patronize their own, and 2 , USFDA requires the company to do a Study (which cost alot) in the US before giving its approval, and the problem is, it's already out of patent, so if the company registeres and approved it, it's easier for other companies to copycat a generic with lower cost - profitability. But Triflusal is safer than aspirin, clopidogrel, and even cilostazole.

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