Comparing Bupropion 150mg Xl Tab (a101) To Bupropion 150mg Xl (681)

Instead of bupropion 150mg xl tab 150mg 24hr (A 101), I received bupropion xl tab 150mg (681). Will it last 24hr like the (A 101) pill will? They said it would, but I have doubts.

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Hi Marci,

From what I could gather, both pills are reported to contain 150mg of Bupropion in extended release form (A101 being a brand name Budeprion XL / and 681 being a generic form of Bupropion XL). So if the extended release tablets are supposed to last 24hrs I don't see any reason why this other pill wouldn't hold true to that. However it seems to me that the only way to know for certain would be to actually try it and see for yourself since everyone responds to these medications differently based on tolerance and other factors.

Things like binders/fillers have been known to impact bioavailability and therefore a medication's overall effectiveness between various manufacturers. Not only that but because the "681" pill is a generic, the FDA also allows the actual active ingredient (Bupropion) to have a plus or minus 20% variability in peak plasma concentrations. With that said, there are many things to take into consideration when determining how long something should last in comparison to a different manufacturer's product. At the end of the day, do you trust the label or your own personal experience?

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