Zydus 10mg Oxycodone Underdosed? (Page 6) (Top voted first)

Hello all. For the last 6 months, i've been prescribed various meds/treatments/pain meds for severe head pressure and neck pain. I had to stop taking any form of Hydrocodone because it makes my skin breakout in open sores (gross, i know). On May 6th, my PCP prescribed me Oxycodone 10mg 4times daily with great results and it made me very fuctional. He gave me another script for the same medication and when i went to the pharmacy, they filled it and when i got home, i notices the tablets/drug company was different. Well, was i in for a suprise. The new generics my pharmacy had were made by Zydus Pharmaceuticals and are imported from India? Well, to say the least, i've been taking almost twice my dosage to get the same effect. There's no way on earth that my tolerance doubled in less than a day! Now, my PCP thinks i'm trying to get more pills, and the pharmacy thinks i'm crazy. The first prescrption i got the 10mg oxycodone from this manufacturer: KVK Tech Inc (pink and "k 56" imprint on them. And they worked fabulous. These Zydus ones seem wayyyy underdosed as i'm taking around 5-6 tabs compared to 4 tabs of the KVK Tech brand. Any info/advice is greatly appreciated!

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Last week I switched from CVS to a local, independent pharmacy. Prior to last month I had been taking two 10mg Percosets daily. Last month my Dr switched me to same dosage Oxycodone IR, which I had filled at CVS and the manufacturer was KVM. I was shocked at how bad it sucked. It did nothing for pain & there were zero pleasurable effects that are a slight perc for being miserable & pain ridden. After going to CVS last week to pick up all my other meds (blood pressure, anti-depressant, vitamins...) & being treated so rudely by the tech & pharmacist I had enough. I told them to keep their meds & I was transferring out. I researched & decided to go with a local, independent pharmacy. When I learned they used Zydus for their Oxycodone manufacturer I Googled them & was so upset about the awful reviews. I had found a couple wonderful, kind, friendly pharmacy but they used Zydus for this med. The pharmacist was kind enough to offer to ordering me another manufacturer but I was totally out of meds at that point & I said I'll take the Zydus but next month would try something new. When I took the Zydus for the first time, I honestly didn't expect any pain relief based on the awful reviews but was I in for a surprise. It not only took the pain away better than any of my prior pain meds, but it knocked me on my ass & reminding me of the first time I ever needed to take a pain med. I was totally shocked, trust me. The next day it was the same & tonight being the third night is exactly like the first. With the Percoset & Oxycodone from KVM I had to potentiate with Tagamet, Quinine & White Grapefruit before each dose because my tolerance had built so much & 20mg were doing almost nothing but I didn't want to increase my dose. With this new med I haven't potentiated once & with the way I feel from it, think it would be too dangerous to do so and there is zero need. Needless to say I will tell the pharmacist Monday that this manufacturer is more than fine & I shouldn't have listened to others people's opinions. Maybe Zydus was losing business from all the bad publicity & decided to up the strength of active ingredient? Maybe this batch is a total fluke & it really does suck (I really hope not). In another post I read somebody cuts their pills for their proper dose & they were crumbly like chalk. I had to cut my pill in half because tonight I actually took less & my pills are so rock hard that a knife has a hard time cutting through them.

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@Frufru
I had the same exact experience as you! When I switched from Percoset 10/325 (2 taken in evening together) to KVM Oxycodone 10mg (2 taken in evening together) they took about 45 min to kick in & did almost nothing for my pain. I switched to a small, independent pharmacy last week & they carry Zydus. I was very unhappy with is because of the awful reviews I read but decided to try it for a month. The Zydus works so well that I am able to take a bit less than I usually do. Where does it say on your prescription that it's manufactured in the US? I want to see if mine is also & maybe that's the differentiating factor between the variances I'm reading about...

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Frufru
Zydus generics are not made in the U.S. Zydus USA is owned by a family in India. Zydus USA is located in New Jersey but all their generics are made in India. Cadila is the parent Indian company. Almost all Indian pharma companies have had problems with the FDA including Zydus Cadila. According to the FDA there are 526 drug manufacturing plants in India making products for the U.S. market. Many of these plants have gotten into trouble for manufacturing and disclosure problems. The FDA has ONLY 10 investigators to cover the entire country, and that is up from past years when there were even fewer FDA feet on the ground.

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Hi there so I just want you to know that the np 12 pill is the exact same as the k 56 pill 10mg just different manufacturer. Same dose ext. Ppl just don't like switching brands it's all mind over matter they do work the same. I used to be a pharmacist I know this stuff.

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