Xarelto And Fatigue
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Second time around for DVT in my legs this yr. The first time three yrs ago, I was on Coumadin for a yr and recovered well. This time on Xarelto. I felt OK for a couple of months, but now heavy exertion is not possible because of fatigue. I am suspecting that Xarelto is messing with my blood chemistry somehow to cause fatigue. Is this a known side effect? I now take 20mg a day. Would reducing to 10mg help? Or should I be on something else?

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I think that side effects are not at the top of drug companies' priorities. It would have to be something very serious impacting a large percentage of users before they would take action. "Fatigue" is very vague. How in the world does one prove that a medicine is the cause? I don't have any plans to discontinue Xarelto to prove my point. My concern is that Xarelto is actually interfering with the operation of the mitochondria on a cellular basis. The mitochondria are the engines that give a person energy. There are actually quite a few drugs with mitochondria impacts. One well known example are statins that lower cholesterol, like Lipitor or Crestor. I'll keep looking into this. I have yet to consult my doctor, a blood expert, about this. I will soon.

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Hi Jim, Sorry to hear about your situation. According to the US National Library of Medicine, "unusual tiredness or weakness" is listed on the side effect profile for Xarelto. The only strange thing I'm finding is that they have this side effect under a category called "Incidence not known". Perhaps it's been reported by other individuals before, but haven't conclusively decided whether or not it was related to Xarelto. However, I don't know why they would even bother to list it if they were unsure if Xarelto was the actual cause.

Maybe you can print out the following page and bring it to your doctor for a second opinion:

ncbi.nlm.nih.gov/pubmedhealth/PMH0045374/#DDIC603481.side_effects_section

NOTE: "leg weakness" is also shown as one of the more common side effects

I hope this helps!

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