What Is Trazodone Made Of?
UpdatedWhat is in trazodone? Is it minerals, plant derivatives, or synthesized chemicals? If so, what minerals, derivatives, or chemicals go into it?
2 Replies
Interesting that there were no answers. I also want to know.
Here's what I found so far:
"Trazodone hydrochloride was originally synthesized in 1966 by Palazzo and Silvestrini in the chemical laboratories of the firm Francesco Angelini. The molecule consists of a triazolopyridine ring and a phenyl piperazinylalkyi moiety.It is the first trazolopyridine derivative to be used clinically, and therefore, represents a new chemical class of antidepressant drugs. its development was a result of an organized approach rather than fortuitous discovery and was based on the hypothesis that the mechanisms responsible for physical and mental pain are the same." [1]
"Trazodone is a triazolopyridine derivative and a phenylpiperazine that is chemically related to nefazodone and etoperidone, each of which are derivatives of it." [2]
Yes, a lot of technical jargon, but it was put together (synthesized) in a lab.
References:
[1] Page 695, Profiles of Drug Substances, Excipients and Related Methodology
[2] Chemistry, Trazodone Details
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