David Says:
Stayhist
Updated
June Says:
Can you use Amoxicillin and Stayhist together?
1 Reply
1
Hi June,
Based on my research there are no drug interactions found between Amoxicillin and Stahist. This does not necessarily mean no interactions exist, but my sources state that every effort has been made to ensure that the information provided is accurate.
With that said, I would personally deem it safe to take these two medications together.
Stahist does have an interaction with grapefruit juice however, which states that: "the coadministration with grapefruit juice may delay the absorption and increase the bioavailability of oral scopolamine (one of the active ingredients in Stahist). The proposed mechanism is delay of gastric emptying as well as inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall induced by certain compounds present in grapefruits. In an open-label, crossover study consisting of 14 subjects, the consumption of grapefruit juice (compared to water) was associated with a 30% increase in mean systemic bioavailability and a 153% increase in time to reach peak serum concentration (Tmax) of scopolamine. However, the perceived pharmacodynamic effect of the drug, as measured by % change in subjective alertness compared to baseline, was similar after coadministration with water and grapefruit juice. Based on these findings, grapefruit juice is unlikely to affect the overall safety profile of of scopolamine but may delay its onset of action following oral administration. However, as with other drug interactions involving grapefruit juice, the pharmacokinetic alterations are subject to a high degree of interpatient variability."
I hope this information helps!
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