Side Effects After Long Term Usage (Top voted first)

After twenty two years on amitrypt 150mg at night for treatment of neuropathic pain I am now suffering from an inability to stabilise my body temperature ? Due to damage done to my hypothalamus by taking this drug I am constantly sweating profusely and going hot then cold no matter what clothes I am wearing or what the weather is like. I recently stopped taking it having been put on other drugs for depression and bitterly regret the years I did spend taking it when the only side effect I was told about was a possibility of an increased appetite and weight gain Please can someone tell me more about the damage to the hyper thalamus and whether it as I fear may be a permanent factor of my very uncomfortable lifestyle

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Hi Mary,

Based on my research, there are actually government studies which have been done, suggesting that Amitriptyline is responsible for decreased activity of the hypothalamus (which regulates body temperature).

If you run a Google search for "Amitriptyline hypothalamus", you should be able to find some of those articles verifying this. However I haven't seen anything just yet in regards to how long these effects might play out for.

Because you've been taking this medication for so many years, it's likely that your body adapted to having it on a regular basis and has to start learning to function without it. That said, the withdrawal effects from 22 years of use may just end up lasting a lot longer than the typical time frame in which people tend to experience such symptoms.

Have you tried using any natural alternatives such as cayenne pepper, exercise, or even just drinking plenty of alkaline water, to help stabilize your body temp on a daily basis?

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