Side Effects Following Prolia Injection (Page 4)

I am 60 yrs old and suffer from osteoarthritis, osteoporosis, and myofascial pain syndrome. After discussing with my endocrinologist, I received my first injection of Prolia two days ago. Had diarrhea approximately 12 hrs later in the middle of the night. Awoke the next day with headache over entire head and face. That evening (12:30 am) I vomited approximately 10 times in succession. Awoke 5 hrs later with terrible pain and tightness from the top of my head down my neck, shoulders, and upper back. I am frightened to see where the pain will travel next, especially after reading the posts on this forum. Is there a drug out there to counteract the Prolia. I will definitely not be getting another shot in 6 mos. My doctor told me that the main side effect of this drug is worsening of skin conditions, such as eczema. Does anyone have any suggestions?

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Nikki~The only thing I know is that 500mg of Magnesium will keep the muscle pains down. Find a brand your body can tolerate. Get to a Rheumatologist and have your immunenoglobulins run. That will show what's going wrong with your body. If you get the skin problems, the only thing that helps that is Prednisone and be careful of it. Come off of it very, very slowly or your blood will go crazy and you will have worse problems than Prolia. Be careful where you go because your immune system is not working well now. Try to get someone else to buy groceries or have a store deliver them. Hopefully, with a Rheumatologist your worst symptoms will disappear. Some work with Immunologists. Take beyond excellent care of your teeth even if you feel horrid. For certain pains there is acupuncture and dry needling. They are close to the same thing except insurance pays for dry needling because it's from a Physical Therapist. Hopefully your Prolia journey will be a short one and an easy one to manage. If your heart seems off, get to a Dr. immediately and if you feel an unusual pain in your hip=ER. Be well~

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I have been on Prolia for for years with no side effects. In fact I am delighted that it is the first osteo med to actually effect my bone density.
Have had osteoporosis since 2000, taking every med there is out there with no effect until the Prolia. Granted I have severe pain constantly from my broken arms and fused knees, so perhaps if the shot causes pain it is not noticable to me, but never had vomiting or anything else from my shot.
Meds react differently on different people so
Maybe you were just unlucky and I am fortunate but I would never give up my
Prolia shots!

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I've just begun prolia and glad to read your post. so far a little swelling on occasion of my lip..and itching.

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Hi Poodle,
I asked about the Calcitonin. She was pretty meh about it. She wanted to try me on a new drug called Tymlos, you have to give yourself a shot in the stomach with it every day. The needles are so thin and little you can barely see it. BUT, it is tremendously expensive even if insurance pays for some of the medicine you're looking at over $1000 a month.
She isn't a full-fledged rheumatologist and she tried to tell me there aren't any side effects or they were minimal to Prolia. She does good on many aspects of my health care. This happens to be one I think needs rethinking. I have an appointment with my rheumatologist the next time I go in.

I want to see what he says. For the small amount of gain, I don't think the Prolia is worth it. I'm wondering what will happen if I don't take anything. If the chronic fatigue wasn't so bad I could make it to the fitness center, and do the weight machines consistently.

Anyway, the Calcitonin isn't out of the picture yet. I'll see what he says.

Hugs to you!
Nikki

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Nikki~have you, yourself, looked up the side effects of this drug. it can cause bone cancer and hypercalcemia (too much calcium). Please check on it. Yes, I know they don't like Calcitonin because it's old and no one makes any money by prescribing it. Remember: The best patient is an informed patient so we don't want to go from horrid to bad. Be well~Pood

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Poodle-you sound extreme along with others on these side effects, which I have always attributed to my osteoporosis level and living with broken forearms due to weak bones that wont heal. Idk what immogloulins are or what they are connected to Prolia for but recently I have had teeth problems. My front crown fell off so need new one to fit, but last week my back molar got loose now is throbbing like needs cavity filled. I have always had good teeth-this scares me so curious if maybe Prolia doing something? Or just old age (65)? Does Prolia get out of system if quit it? I took Fosamax over 5 years found out it never leaves system. Prolia is only thing that stabilized my bone loss. There was Forteo shots but they were liited to 2 yrs only allowed. Any help welcomed.

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I looked up the side effects and wrote them in the little planner I use for medical information. Then, I highlighted the ones specific to me. The Calcitonin wasn't ruled out she was reluctant to try it. I see the rheumatologist the first part of September. They are working on an oral pill for Calcitonin. It's in the second or third stages of testing. I've got the time to get the information on Calcitonin and I already have the Prolia symptoms written down. I confronted E the PA and asked her why I wasn't given Calcitonin as an option. She said it's been around for a long time but many doctors don't use it. E is normally fine as my arthritis, FMS and CFS are fairly stable at the moment. Yay! So, after my visit with her, I'm going to see the rheumatologist and see what he says. He's a great doctor and I trust him.

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Lynx~did your teeth die at the gum line? That is from Prolia. True and simple. Prolia is a biologic so it has half lives. In 16 days 1/2 of the Prolia leaves your body, then in another 16 days 1/2 of the remaining half is deleted until only a monocle of Prolia is left in us. That does not mean in the least that the damage to the human body leaves when Prolia does. It causes major damage to a human body up to and including death. Please report all your problems to Amgen, the manufacturer who is bound by law to report it to the governing body of drugs in your country. If you are in the US it would be the FDA. You wonder what immunoglobulins are. They are a special blood evaluation that monitors extremely important information about or health, e.g., if AIg is down, it means you have Celiac Disease and the others are just as important as to your REAL overall health. You may want to do a net search on them and find out about them and how they tell the real truth of what's going on in your body. My immunologist helped stabilize mine so I could get well by the 6th month end of the one and only inj. of this poison. I personally believe Prolia has a little more of it's twin, Xgeva, in us that they don't want us to know. The twin is for treating cancer. That in itself may tell you many things going on in your body. If I can be of any more assistance, please let me know. Currently in the US there is only one legal suit against Amgen and it is for the broken femur. I'm beginning to believe the teeth dying at the root should also be included because it is such an impossibility while the whole top of the tooth is healthy and cavity free. Be well~

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I am a 65 year old woman in 5th stage kidney failure and on peritoneal dialysis daily. I took the prolia injection 6 weeks ago.. Since then I have had: tingling in hands and feet, jaw pain, nausea, vertigo, low magnesium, and low calcium. I had my fifth calcium infusion today. My labs came back with my BUN going from 34 to 71. I emailed my nephrologist and his reply was that prolia has probably damaged the residual kidney function and thus the BUN has gone up. I will have to increase my dialysis either in volume, number of exchanges or length of exchange. I am not taking the second injection and advising everyone I know to stay away from it.

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Poodle help me with this. My reaction to the prolia was a severe skin reaction. I can not use my beloved essential oils without an itchy rash occurring. I am 7 months out from my 3rd inj. So even tho the prolia is only one cell thick, does this mean i will always have skin sensitivities, as i react to other things i never had a problem with before? Thank you for your consistent presence on this site.

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Judith (# 40) --

So sad to hear that your mother died of this poison. I hope you can do something legal against Amgen. It is criminal that they continue to sell us this horrible drug that has caused so many more serious health problems than weak bones. My condolences to you for the loss of your mom.

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Lois-
There is no antidote for Prolia. My journey approaches the year 2 mark 01/15/18. My best advice from experience is have a doctor who can manage all your side effects be your "contractor" as necessary side effect problems are subbed out. Your doctor needs to understand that Prolia is the root cause and treat side effects as such rather than new conditions,illnesses, diseases or whatever...
all need to be addressed but my crazy cough was not copd, my diareah not a GI issue needed colonoscopy and GI workup. My weakened urethra doesn't need surgery, and my gluten and milk sensitivies are not more than that - just worse... my muscle and bone pain is real. My fatigue is life stopping- help me treat the symptoms without going overboard as I wait for Prolia to leave my body.

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Re: Elaine (# 70)

It's true that the Prolia is gone but that does not mean in the least that it does not cause havoc on and in the human body. If you have not been on Prednisone before for your rash, you need it now. 10mg/day. It makes osteoporosis worse but you do need help. You can also make an appointment with a Dermatologist or an Immunologist. I would also suggest you order Nutrashield. It's a lotion the nurses in hospitals use for their hands as they have to 'alcohol' them every time they come in to see a patient. I'm not aware of it being in any stores. It also prevents diaper rash. Non-allergenic and Non-sensitizing. The Pred. will get rid of the rash and you can have it for up to one year if absolutely necessary. Most Drs. only do small packets of it so your best bet is a Rheumatologist for it. Just don't let them give you any more biologics! This should calm your skin down to 'normal'. Just don't quit it too soon or it could reappear. The longer you have Pred. in your body, the less Prolia can bother your current problem. Hopefully, it will resolve with the Pred. and the new lotion. I am so very sorry you are suffering from this. You can also use acupuncture or hypnotherapy to get rid of this skin problem. With hypnosis, the 'mind that runs our bodies' can be changed to forget you had Prolia and can change you back to before you had any inj's. of Prolia but it would take some time and a very qualified hypnotherapist of which there is not an abundance in the US. If you live near Tennessee I know an excellent one, and in Wyoming, California and Washington State too. I also know of one in Colorado but I don't know her well enough to recommend her work. Now you have some hope and choices to make. Be well~

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Re: Poodle (# 65)

Hi Poodle, I always look forward to reading your posts. I asked about the Calcitonin on my last visit. My Rheumy said the Calcitonin won't help plus it isn't something easy to get anymore. I'll check into seeing if an immunologist is something Medicare will cover and continue looking for other avenues until we're offered something that will actually work. I've been reading that most people's diets are too acidic and if we try to balance it out and eat foods rich in calcium, B vitamins and other things vital to bone health along with exercise such as walking it can help.

More research is needed, in a bunch of areas.

I appreciate all the knowledge you share Poodle and everyone else here. I don't feel like I'm fighting this crap alone anymore and that helps.

Hugs to all!
Nikki

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Re: Nikki (# 74)

Yes, they are stopping Calcitonin. Drs. hated it because no money in it for them. If you have not had blood clots (DVT's/PE'S) you can take Evista. It's an old one that still works too. There is also the one that Merck still makes but they have been sued over and over about it so I, personally, said no which at present leaves me with zero choices. Doctors can be a real problem. They seem to be in love with biologics and biologics all have the same thing in common -- diminishing our immune system. Be well~

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Re: Poodle (# 75)

I'm 75, was not on drugs, spent 30 years at a gym and was pretty healthy. I had one injection of Prolia on March 1, 2017. Did not do my research and really regret it or I would not have gotten it. I had reverse total shoulder replacement in late 2016 and my Ortho said at a followup that I had weak bones when he did the surgery and needed to get on Prolia right away. Afraid that the prosthesis might come loose, he sent an order to my endocrinologist. I have osteopenia and have had a stress fracture in my knee, and in metatarsals. I asked a friend who was on Prolia if there were any side effects and she said "no". The nurse who gave me the injection said the only side effect could be at the injection site. WRONG!!! Three days later I had severe muscle, bone and joint pain which continues to this day. 9 months later I had pain in my abdomen and had to have a CT scan which showed nothing. A month later while I was doing well in physical therapy for my shoulder surgery, got severe pain in shoulder which affected my recovery. By April, the pain in my thighs was so severe I could hardly walk (and I previously could walk 3-4 miles with no problem). I've had MRI's for my hip with no diagnosis and an MRI of my spine. The orthopedist says I have sciatica and the pain is so severe that my leg twitches and I have trouble sleeping at night. When I get out of my SUV or a chair, I have to stand for a few minutes to see if my legs will work. And here's a kicker....I got a severe case of shingles September 1st and continue to have post herpetic neuralgia --terrible pain-- which my doc says was caused by Prolia lowering my immune system. I had gotten the shingles vaccine. And now the final straw today. My eye doctor concluded after many evaluations that the severe pain in my eye is probably Prolia related because everything he looked at in my eye was normal. So, thanks to my failure to research Prolia before the shot, I am in severe pain everywhere. And I wouldn't wish this nerve pain from shingles on my worst enemy. I'm very depressed. If it weren't for my sweet husband I'd take a bottle of pills and call it a life.

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Re: Daisy (# 14)

Hi D. I am also a victim of a GP who recommended Prolia to me. It was administered to me circa 8 months ago, I received it into my belly. Since I had it I have lost all my muscles and 28 lbs in weight. I have excruciating rectum pain, especially at night or when I sit. I am extremely worried about my spine. Has anyone noticed memory loss ans confusion. Did your doc ask you to sign a disclamber? I do not trust GP's and drug companies. I spoke to a person who warned me not to touch Prolia.decause it is one big experiment . I have developed insomnia since I Received this drug which I have good reason to believe was first manufactured by the Nazi's

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Re: SusiQ (# 76)

I'm so glad that you have a sweet husband. Yes, another side effect is depression, something that I have never known in my life even after burying a lover years ago and then my lovely husband. I find that if I drink plenty of water and I mean plenty, that helps the bowels and the spirits. I also take Omega oil 3,6,7,9 and find it excellent. Wash with Silcocks base and moisten the skin with the same. Hope we all feel better soon. I hope to go for a good walk later today.

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Re: Mad Bid (# 77)

Oh my goodness! I have not heard anyone else mention rectum pain. I get it when I have had a few no diareah days... it's like a pain pressure... but no constipation or gas or anything... thank you for sharing...

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Had my first injection 3 months ago. Before the injection I researched the side effects of this drug. I was concerned and brought in the side effects. My biggest concern was the constipation. My whole family suffers from motility problems. The study I looked at most people stopped taking it because of the constipation. My doctor said he had not heard of that in any of his patients and that we were out of options. He said most people who have constipation don’t hydrate or exercise. The constipation is horrible. After finding this site and reading everyone’s side effects I'm not sure I will get another shot. Actonal caused me to have gastroparesis. My doctor didn’t believe me. I took myself off of that med and it took 5 months to get out of my system and then I was ok. All meds have side effects. Medicine is not individualized. We know our bodies better than the doctors that treat us. Most of the etiology of medications is unknown. Not sure what my next move will be...

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