Reaction To Combining Alcohol With Lyrica Pristiq And Oxycodone (Top voted first)

I am prescribed Lyrica and Pristiq for Fibromyalgia and depression and oxycodone for occasional pain from knee replacements. I have on occasion drank 2-3 alcohol drinks while taking this combination with no problem but the past two times I am totally fine when I go to bed but I wake with the worst hangover and it lasts for days. The last time, 3 weeks ago I had 2 beers, took the oxycodone (10mg) an hour later, took the lyrica and pristiq 5 hours later before going to bed and woke the next day really hung over with nausea every time I moved my head too quickly and I've had headaches and my thinking has been foggy ever since. For 3 weeks!! Could this combo have damaged something in my brain? Has anyone experienced this, or heard of this? Will this go away?

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Combining the medications with alcohol can cause worsening of the side effects, which would explain the symptoms you've experienced. And it could happen at any time, even if you've never had such a problem before, which is why people are warned not to drink when taking such medications, it's an unpredictable thing.

It's most likely from combining the alcohol with the Oxycodone.

Learn more Oxycodone details here.

You might want to avoid alcohol consumption, or skip taking the Oxycodone, when you are having a few drinks.

Have you talked to your doctor about it? They will have more ideas than I do as to other possible reasons.

The chances of there actually being brain damage isn't likely to occur with so few drinks, though you might also want to check that with your doctor.

Another important thing to ask is how much water do you drink? It is possible that the alcohol is creating some dehydration, which is being made worse by the hangover symptoms and could also explain why it lingers for several days.

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Alcohol and oxy, will give you a head pounding, no seeing,no moving, think your blood vessels in you head are about to explode migraine from hell! it's pretty scary!!!!!!

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