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Prucalopride - Dosage Changed

Updated May 18, 2018
Pragmatic Says:
Wed, May 16, 2018

Taken prucalopride for approx eight months with good results but it did stop working.

Realised it had stopped since taking baclofen (changed from diazepam due to hype).

Even after months of meds being changed the prucalopride was no longer effective.

Research states taking more than the prescribed dose does not work but out of desperation I tried 2mg both morning and night with instant results.

Bowel Clinic has confirmed I can continue this if it works for me. She states there is just no evidence that Prucalopride works by increasing the dose.... Sadly there is no system to show the feedback that it can sometimes work.

I will try returning to the advised dose after regaining continuity and use the am-pm doses for a booster when required.

Presently so grateful not to have life on hold and housebound with the condition....annoyed that all info states not to increase the dose!

Glad to hear the Dr say that they just don't have enough proof/results regarding increasing the dose....

1 Reply

1
Verwon Says:
Fri, May 18, 2018

Yes, unfortunately, what they told you is true, they do not have any proof that a higher dosage works better, but we are all different and our bodies are different, so it is possible that you can get different results in response to the higher dosage, than other people.

The NIH warns that it may cause decreased appetite, fatigue, nausea, and palpitations, according to currently available studies.

What other medications are you taking? I wonder if some of them may be a contributing factor?

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