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Oxycodone Vs. Morphine (bio Availability Question)

Updated June 27, 2021
Joseph twang Says:
Wed, July 26, 2017

I understand oxycodone is 1.5x stronger than morphine, but does that take the oral bioavailability into account?

I've seen someone say 20mg of oxycodone is equivalent to 30mg of morphine, but is that taking into account that only 30% of the morphine is absorbed by the body whereas with oxycodone it's about 80%

So when taking 30mg of morphine you're body is really only getting about 9mg but when taking 20mg of oxycodone you're getting 16mg of it absorbed into your body.

I think I am going to be switched from 30mg of Morphine to 10mg of Oxycodone, in terms of bioavailability that means instead of my body getting 9mg of morphine, I'll be getting 8mg of oxycodone instead. Will this be as effective?

1 Reply

1
VerFree Says:
Sun, June 27, 2021

Yes, all of this is taken into account, when the medications are studied, and the drug conversions are recommended.

Whether or not any given medication, or dosage works for you, however, it a different matter, since we are all different.

The FDA warns that Oxycodone, and Morphine carry the risk of being habit forming, and may cause side effects, such as nausea, constipation, dizziness, headache, and dry mouth.

How is it working for you?

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