David Says:
Nitric Oxide Conversion To Peroxynitrite
Updated
Rachel Says:
This question is about the effect of peroxynitrite on cell death. Increasing PN production, decreases NO production (NO is scavenged in the process of creating ONOO-). However, the concern/thing that we didn’t understand was why PN doesn’t instantly kill cells since it’s a more potent radical. Sure, you decrease NO, so maybe you get less death that way, but you’re replacing it with something that seems like it would be even worse. So, why do you at least initially get less cell death?
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Interesting observation here. Perhaps the naturally occuring presence and activities of antioxidant enzymes and their roles in PN-induced cell death (both apoptotic and necrotic), is a major determining factor of its cardiotoxicity or carcinogenicity; effectively preventing peroxynitrite from being more destructive towards cells.
This is just my own theory, but hopefully someone with an extensive background in this field can offer more lucrative advice...
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