Naproxen Allergy Vs Advil

A few years ago I started to get arthritis pains in my hands late at night, in colder weather/water and after using them a lot. I was told by my grandma I probably have it because it runs in both sides of the family. I took naproxen once and broke out in hives/skin rash on my arms. I no longer take it but I can take Advil with no problems whatsoever. All doctors are very confused by this as they are apart of the same family. I'm confused too. Is there a reason why I can take one but have allergic reactions to the other?

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That is always possible, since no medication is exactly the same as another, when it comes right down to the actual base chemicals. For example, I can take most antibiotics without a problem, but had a bad allergic reaction to Bactrim. It really isn't always the class of medication that causes the problem. I am also allergic to some blood pressure medications, but can take others without any issues. It is just always kind of a trial and error situation.

However, according to NIH reports, you should be aware that you may find other medications you are also allergic to, so please be careful.

Is there anything else I can help with?

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