Medicine That Can Be Tooking Together

COULD YOU TAKE TRAZODONE WITH NEXIUM AND CITALOPRAM 40 MG AND IF YOU ALLERGY TO SULFA

REPLY

REPORT

Hi Tea,

Based on my research, I would not recommend taking any of those drugs together. Serious interactions are present between Trazodone and Citalopram, as well as between Citalopram and Nexium. The only combination deemed "safe" would be Nexium + Trazodone.

The interaction between Trazodone + Citalopram notes the following:

"MONITOR CLOSELY: Concomitant use of agents with serotonergic activity such as serotonin reuptake inhibitors, monoamine oxidase inhibitors, tricyclic antidepressants, 5-HT1 receptor agonists, ergot alkaloids, lithium, St. John's wort, phenylpiperidine opioids, dextromethorphan, and tryptophan may potentiate the risk of serotonin syndrome, which is a rare but serious and potentially fatal condition thought to result from hyperstimulation of brainstem 5-HT1A and 2A receptors. Symptoms of the serotonin syndrome may include mental status changes such as irritability, altered consciousness, confusion, hallucination, and coma; autonomic dysfunction such as tachycardia, hyperthermia, diaphoresis, shivering, blood pressure lability, and mydriasis; neuromuscular abnormalities such as hyperreflexia, myoclonus, tremor, rigidity, and ataxia; and gastrointestinal symptoms such as abdominal cramping, nausea, vomiting, and diarrhea.

MANAGEMENT: In general, the concomitant use of multiple serotonergic agents should be avoided if possible, or otherwise approached with caution if potential benefit is deemed to outweigh the risk. Patients should be closely monitored for symptoms of the serotonin syndrome during treatment. Particular caution is advised when increasing the dosages of these agents. The potential risk for serotonin syndrome should be considered even when administering serotonergic agents sequentially, as some agents may demonstrate a prolonged elimination half-life. For example, a 5-week washout period is recommended following use of fluoxetine before administering another serotonergic agent. If serotonin syndrome develops or is suspected during the course of therapy, all serotonergic agents should be discontinued immediately and supportive care rendered as necessary."

The interaction between Citalopram + Nexium notes the following:

"ADJUST DOSE: Coadministration with CYP450 2C19 inhibitors may increase the plasma concentrations of citalopram, which is partially metabolized by the isoenzyme. In 12 healthy subjects who had received citalopram 40 mg once a day for 21 days, administration of cimetidine 400 mg twice a day for 8 days increased the steady-state citalopram peak serum concentration (Cmax) and systemic exposure (AUC) by 39% and 43%, respectively. In addition to inhibiting CYP450 2C19, cimetidine is also an inhibitor of CYP450 2D6 and 3A4, both of which participates in the metabolism of citalopram. The extent to which sole inhibitors of CYP450 2C19 may inhibit citalopram metabolism is unknown. Clinically, high plasma levels of citalopram may increase the risk of QT interval prolongation and torsade de pointes arrhythmia.
In general, the risk of ventricular arrhythmia in association with QT prolongation is largely unpredictable, but may be increased by certain underlying risk factors such as congenital long QT syndrome, cardiac disease, and electrolyte disturbances (e.g., hypokalemia, hypomagnesemia).

MANAGEMENT: Given the risk of dose-dependent QT prolongation, citalopram dosage should not exceed 20 mg/day when prescribed in combination with CYP450 2C19 inhibitors such as Nexium (esomeprazole). Alternatives should be considered when possible, and hypokalemia or hypomagnesemia should be corrected prior to initiation of citalopram treatment and periodically monitored. Patients should be advised to seek medical attention if they experience symptoms that could indicate the occurrence of torsade de pointes such as dizziness, palpitations, irregular heartbeat, shortness of breath, or syncope."

I was unable to locate specific details regarding whether or not these are sulfa drugs, but I would strongly suggest looking into more natural alternatives if you're unable to continue using this set of medications.

I hope this helps!

REPLY

Was this helpful? 0

Tooken is not a word!




Tooken is not a word in english language!

REPLY

Was this helpful? 0

I was prescribed Gastrocrom and Domperidome, can they be taken together? If so, is there any side effects? ## Hi Julie, ...

1 REPLY

Can We Take Cool Medicine With Wine Together? ## I drink wine everyday but I want to stope now but I can't help myse...

1 REPLY

I have cervical problem as well as classic migrane n depression ,I have been prescribed different medicines by two diffe...

1 REPLY

I am currently on 16mg on suboxone and I want to start duromine for wright loss is it possible to take them together ## ...

1 REPLY

Im on suboxone and being treated for an infection with batrim. Will both still work properly or cancel each other out? #...

9 REPLIES

Flexeril & klonopin taken together ## Hello, Ckw! How are you? Yes, you an take them both, if your doctor has prescr...

1 REPLY

Can I mixed solid tablets together in one bottle for traveling? ## Hello, Jeff! How are you? Yes, you can do that. Howev...

2 REPLIES

My mom has sores under the plate in her mouth. The clinic has given her Ilvitrim 400g tablets. Is it safe for her to tak...

1 REPLY

I have noticed these capsules lying around in my vehicle. I would like to know if it can be used together with Canabis a...

1 REPLY

I have back problems for which they prescribe hydrocodone for. I keep them on hand for times of major discomfort to allo...

1 REPLY