Is Bladder Sloughing Possible After Medication Is Finished?

I have had chronic UTI's my whole life but ran into real problems since 1998 after cystocele/rectocele repair. I had a suprapubic catheter for a few days. I got a nosocomial infection in hospital. Before all my UTIs were E. Coli. I got Kleibsiella pneumonia in my urine & over the years a variety of others. I am on cephalexin 250mg prophylactically because I have interstitial cystitis for the last 10 years. About once a year I get enterobacter aerogenes that is resistant to everything except SMX-TMP. this last time was about 6 weeks ago. Made by Vista. Skin on my hands kept peeling no matter how much lotion I used. I was also nauseated constantly. I was an RN for 38 years until 2010 when IC & fibromyalgia put me on disability. Sorry this is so long but felt background is significant. This is the first time I've ever had this problem. My bladder has been more sensitive than usual ever since. I have my own diagnostic strips & it's negative but I notice what looks like little pieces of tissue, not sediment. Could the medicine have caused this? I never had this reaction before. For 30 years I was on plain old Bactrim prophylactically till 1998 when I became resistant. When I have to take this again, will a different brand make a difference? I had to take 1/2 dose after several days because I was so miserable. I had a different brand available & finished up last few days with that instead & didn't have skin sloughing & nausea that I had with Vista.

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This antibiotic has been known to cause most of these issues as side effects in some people that take it, as reported by the FDA. It could also cause dizziness, headache and diarrhea.

However, I'm not finding anything about the bladder sloughing. That is something I'd definitely recommend consulting your doctor about.

Has anyone else experienced this?

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