Inquiry About Bioflu And Isoniazid

I am taking prescribed medicine Isoniazid, can i take Bioflu when i have fever,colds and cough? Is there any contraindications? Thank you.


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I am taking prescribed medicine Isoniazid, can i take Bioflu when i have fever,colds and cough? Is there any contraindications? Thank you.

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Acetaminophen, one of the active ingredients found in BioFlu does have an interaction against Isoniazid. This interaction states the following:

MONITOR: Some reports have suggested that isoniazid may increase the potential hepatotoxicity of acetaminophen. The mechanism may be related to induction of CYP450 2E1 metabolism of acetaminophen to toxic metabolites during concurrent administration, or transient increased metabolism of acetaminophen after discontinuation of isoniazid. Study data have been conflicting and causality is unclear due to the presence of other drugs in some cases. Both isoniazid and acetaminophen have individually been associated with hepatotoxicity.

MANAGEMENT: Until more information is available, concurrent acetaminophen use should be limited. Close attention should be paid to clinical and laboratory evidence of hepatotoxicity. Both drugs should be discontinued if evidence of hepatoxicity is observed. Aspirin or nonsteroidal inflammatory agents may be safer alternatives.

In light of this, I would only take these mediacations together for a short period of time, if you are able to, and possibly consider natural alternatives to BioFlu if you must take isoniazid long term.

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