I'm Afraid To Start Taking Bupropion With Tramadol (Page 2) (Top voted first)

I was just prescribe Bupropion 150mg 2x daily. I also take Tramadol which was prescribed by the same Dr. I'm afraid to start the Bupropion because of the drug interaction btwn the two. Should I be worried? Can I cut the tablets in half & take 75mg 2x daily?

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I've been on 2 Tramadol 50's taken 3 times a day (total of 300mg of Tramadol a day) taken with a Wellbutrin 300XL for many years with zero problems but I'm also on seizure medications that are actually prescribed for my nerve and musculoskeletal pain. I'm on both Lyrica 300mg per day and 1200-1800 mg a day of Gabapentin each day so I think the fact that I take seizure meds for my pain this keeps my seizure threshold very low.

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Re: chalupa batman (# 9)

400mg of tramadol is above the daily recommend dosage and that alone can cause seizures. Low dose tramadol in most people can be taken with wellbutrin.

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Re: John j (# 26)


I'm sorry to hear you're in pretty close to the same predicament as my husband. Our lives were turned upside-down because of these meds. My husband took these meds together, had a seizure while driving to work (witnessed by passers-by), tapped and pushed along a car with a mother and child inside, crossed a 5-lane highway, passed through a barbed-wire fence, and then hit a tall concrete culvert. He had an aortic dissection, GI tract removed, and a head injury-concussion and more. He probably won't ever be able to work or drive again, is on disability, and he's just in a lot worse shape than we ever expected at this age. All I can say is, it takes time, but the new normal gets better as you go along and re-adjust, and then you come to the point where you appreciate everything you have, because you realize you almost lost it all. Part of me is still angry that one doctor is not paying attention one day, coupled by a pharmacy that should probably have insisted on counseling and didn't, contributed to hard times for our family. It's very important to get the word out!

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Re: Wynn (# 18)

Prazosyn is very good for night terrors and night mares.

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Re: David (# 1)

I'm prescribed Xanax, Ativan and Lyrica. I thought it was an allergic reaction to the Lamotrigine I was originally trying to take but didn't know they were sold under the same names being generic and/or brand name.

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also, bupropion and welbutrin are not SSRIs which is probably why the dr prescribed them together.

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Hi, my dose if bupropion (wellbutrin) was upped to 300mg last week. For a different chronic pain I take 400mg of tramadol over the course of the day.
Last night, I was on my own and I fainted. When I came to I had no idea why I was on the floor and was very confused. I don't remember falling at all. The doctor sent me to hospital but said my blood pressure and blood test were normal so I probably just fainted. I'm not so sure. They've said not to stop taking the bupropion .

What was your experience with having a seizure? How could they tell it was a seizure? What tests did they do? How did u feel afterwards? Did u have a headache/feel really sleepy? I'm just a bit concerned.

Thanks

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Good for you...neither does the warnings relate to bupropion proscribe the combination. In fact doctors commonly prescribe bupropion and SSRI's such as prozac together and tramadol is only a weak seratonin uptake inhibitor.

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Both medications taken together lower the seizure threshold, and the effectiveness of Tramadol may be decreased by Bupropion.¡

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Hi Donna,

After looking over the interaction between these two medications, I can certainly see why you might be scared to take them together.

The interaction I found states the following:

"MONITOR CLOSELY: The risk of seizures may be increased during coadministration of tramadol with any substance that can reduce the seizure threshold, such as selective serotonin reuptake inhibitors (SSRI antidepressants or anorectics), monoamine oxidase inhibitors, neuroleptic agents, central nervous system stimulants, opioids, tricyclic antidepressants, other tricyclic compounds (e.g., cyclobenzaprine, phenothiazines), carbapenems, cholinergic agents, fluoroquinolones, interferons, chloroquine, mefloquine, lindane, and theophylline. These agents are often individually epileptogenic and may have additive effects when combined. Many of these agents also exhibit CNS- and/or respiratory-depressant effects, which may be enhanced during their concomitant use with tramadol."

"MANAGEMENT: Caution is advised if tramadol is administered with any substance that can reduce the seizure threshold, particularly in the elderly and in patients with epilepsy, a history of seizures, or other risk factors for seizures (e.g., head trauma, brain tumor, metabolic disorders, alcohol and drug withdrawal, CNS infections)."

Personally, I think depending upon your reasoning for having to take Bupropion, it may be a good idea to consider other alternatives; whether it be natural or just something that you can easily take with Tramadol. I'm not a risk taker when it comes to medications, so I'm sure others will say that cutting them in half is fine, but I don't like to take these kinds of chances with my general well-being. I find it odd that your doctor didn't explain any interactions to you before prescribing the drug. That's just my perspective though.

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