I'm Afraid To Start Taking Bupropion With Tramadol (Page 2)
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I was just prescribe Bupropion 150mg 2x daily. I also take Tramadol which was prescribed by the same Dr. I'm afraid to start the Bupropion because of the drug interaction btwn the two. Should I be worried? Can I cut the tablets in half & take 75mg 2x daily?

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Can you take adderall an tramadol together?

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My 16 yr old daughter had 2 grand mal seizures a few days ago along with a smaller seizure in between and all 3 occurred over an 8 hour period after mixing bupropion and tramadol. Never had a seizure before that. Scary as hell to watch. NEVER mix these drugs!

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Hi Sophie, I also take 400mg of tramadol a day and 150mg of the wellbutrin. The exact description you gave of hat happend to you, happened to me a few months ago. It happened in the grocery store so ppl saw what went down. Everyone i talked to says it was a seizure, and one was a off duty paramedic.

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Which is why bupropion is fine w/tramadol. Good job

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Hi, my dose if bupropion (wellbutrin) was upped to 300mg last week. For a different chronic pain I take 400mg of tramadol over the course of the day.
Last night, I was on my own and I fainted. When I came to I had no idea why I was on the floor and was very confused. I don't remember falling at all. The doctor sent me to hospital but said my blood pressure and blood test were normal so I probably just fainted. I'm not so sure. They've said not to stop taking the bupropion .

What was your experience with having a seizure? How could they tell it was a seizure? What tests did they do? How did u feel afterwards? Did u have a headache/feel really sleepy? I'm just a bit concerned.

Thanks

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24 yr. old female, 5'5", 160 lbs, takes 300 mg Wellbutrin, 150 mg Zoloft, and was prescribed 50-100 mg every 6 hours of Tramadol. After 2 days of being on Tramadol, I had a grand mal seizure and fell and hit my head. NEVER MIX THIS MEDICINE WITH SSRIs.

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I just had a grand mal seizure because I took bupropion 300mg and tramadol 50mg together. I weight 250lbs and 6'4 and have never had any serious illness. I have a high tolerance to all medicine and alcohol, but this seizure came out of now where. Please be careful, and do NOT mix this medicine.

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also, bupropion and welbutrin are not SSRIs which is probably why the dr prescribed them together.

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i've just recently began taking this combination of buproprion and tramadol (each for separate reasons). I'm not sure about the combination, but i do know that if your buproprion is a time release pill, then cutting them in half may not be the smartest thing to do. Maybe just take one a day instead.

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I have taken Wellbutrin 300 mg and Adderall 10 mg in the morning and Ultracet (Tramadol + Acetaminophen) at night the same day and nothing happened. Except that the next morning I woke up with no pain at all :)

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Hi Donna,

After looking over the interaction between these two medications, I can certainly see why you might be scared to take them together.

The interaction I found states the following:

"MONITOR CLOSELY: The risk of seizures may be increased during coadministration of tramadol with any substance that can reduce the seizure threshold, such as selective serotonin reuptake inhibitors (SSRI antidepressants or anorectics), monoamine oxidase inhibitors, neuroleptic agents, central nervous system stimulants, opioids, tricyclic antidepressants, other tricyclic compounds (e.g., cyclobenzaprine, phenothiazines), carbapenems, cholinergic agents, fluoroquinolones, interferons, chloroquine, mefloquine, lindane, and theophylline. These agents are often individually epileptogenic and may have additive effects when combined. Many of these agents also exhibit CNS- and/or respiratory-depressant effects, which may be enhanced during their concomitant use with tramadol."

"MANAGEMENT: Caution is advised if tramadol is administered with any substance that can reduce the seizure threshold, particularly in the elderly and in patients with epilepsy, a history of seizures, or other risk factors for seizures (e.g., head trauma, brain tumor, metabolic disorders, alcohol and drug withdrawal, CNS infections)."

Personally, I think depending upon your reasoning for having to take Bupropion, it may be a good idea to consider other alternatives; whether it be natural or just something that you can easily take with Tramadol. I'm not a risk taker when it comes to medications, so I'm sure others will say that cutting them in half is fine, but I don't like to take these kinds of chances with my general well-being. I find it odd that your doctor didn't explain any interactions to you before prescribing the drug. That's just my perspective though.

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