Hello, Nefer!

I didn't find any problems or interactions listed between these two medications. However, according to the MayoClinic, Hydroxyzine is on the list of medications that is usually not recommended for use alongside Bupropion, even though it may be required in some cases. They go on to note that if both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Ref: MayoClinic

Hydroxyzine is classified by the FDA as an antihistamine that is also used for its sedating properties. Its typical side effects may possibly include nausea, dizziness, dry mouth and drowsiness.

Ref: MedlinePlus (Hydroxyzine)

Bupropion is an antidepressant and smoking cessation aid. Its typical side effects may include nausea, dizziness, headache, dry mouth and mood changes.

Ref: MedlinePlus (Bupropion)