Hydrocodone-apap 5-325 Amneal
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Amneal manufactured, Hydrcodone- Apap 5-325 doesn't work as well as V 3604 or Watson 349. Any idea why?

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Amneal is not effective whatsoever. Secondly, this medication made by this manufacture causes nausea and dizziness. Any other manufacturer is superior. It's terrible!!!!!

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why did the federal government change it from 500 to 325

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Hi Jane,

I think I can help answer your question here.

One of the primary factors that doesn't seem to be well known to the public, is that the FDA allows active ingredients in generic meds to vary by as much as 25% from the actual listed dosage.

This could potentially mean that a 5mg hydrocodone may actually turn out to be 3 to 7 mgs depending on the manufacturer.

Aside from that, subtle differences in the "inactive" ingredients (binders/fillers) could also impact the absorption/overall efficacy of the medication. Put two and two together and you pretty much have a different medication than what you may be used to taking.

I hope this info helps! Have you tried any of the brand-name options as well (such as Norco or Lortab)?

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