Krazeehors Says:
Hydrocodone-acetaminophen 10/325 By Mallinckrodt (Page 3)
Updated
Jennifer Says:
My pharmacy changed my meds from the yellow 10-325 v 3601 norco to the 10-325 white m367 mallinckrodt. I've been taking the yellows for years with no problems. Today I started the whites and feeling dizzy, a little weak, kind of panicky. What is different about the two meds that would cause this?
190 Replies (10 Pages)
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41
I have the same problem. Finally got my doctor to order the kind I need from Actavist Pharmaceuticals.
It is NOT the Hydrocodone. You are experiencing a severe allergy to the Inactive Ingredients.
Also, you need to tell your doctor about your symptoms, and ask him to write for Actavist brand Hydrocodone.
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Opal Says:
I have exactly the same problem! Even with the with name brand Vicodin which is now white. Some generics make my blood pressure go off the charts (Mallincrapt) and others just don't provide pain relief. I was fine on the yellow Qualitest and never felt like I needed more until my pharmacy quit getting the yellow pills. I'm trying yoga and acupuncture now so I can jump off this crap!
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zaborav Says:
Firstly, Jennifer, the brand 'NORCO' is made by Actavis (formerly Watson Pharmaceuticals) & NOT by Qualitest, which is but another generic. Now hydrocodone bitartrate is not available at all outwith the USA - WHO Report 2014 and 2015 both state unequivocally that 100% of the world supply of that drug was consumed in the USA (unless, like me, one has a friend whom is able to get a prescription and send it on to me as required); this since the withdrawal in Europe of Knoll's DICODID, a 10mg tablet prescribed not as an analgesic, but as an antitussive for painful, dry cough. Without, may I add, the addition of acetaminophen (paracetamol) in ridiculously high doses - the actual maximum required for any synergistic effect increasing analgesic effect being around 60mg per 15mg hydrocodone; why they feel it necessary to add so much of that extremely hepatotoxic drug, which by itself has very little analgesic effect and is useful only really as an antipyretic, is a mistery to me as it serves no useful purpose whatsoever. I have tried several of the combination tablets: Qualitest V3601, Mallinckrodt M367, Watson 853 and IP 112 are the ones I recall. As they fill the 'analgesic gap' we have here between dihydrocodeine tartate (its parent drug, hydrocodone being more properly named 'dihydrocodeineone bitartrate') & morphine salts - there is nothing at all between the two in potency on the UK (and other European) market(s) - their availability wouod be a boon for those patients requiring something stronger than 'DF118 FORTE (dihydrocodeine tartrate) 40mg' and weaker than the weakest morphine preparation, 'Oramorph' (which contains so little morphine, only 5mg per 25mL, that bit is not even classified as a Controlled Drug).
My experience is that of the tablets I have mentioned, the 'M367' is by far the most effective, followed by Qualitest's 'V3601' yellow tablet. Recently I was sent the new 'Watson 853' WHITE tablet, 360 of them, and must say that they are the weakest and least effective ever had, why another mystery, since just because the company is now owned by Actavis, the composition of the tablet should never have changed; the same thing may be seen in the now-Actavis-owned Purepac yellow 2mg alprazolam tablets, which now feel considerably weaker than before. There are (out of literally hundreds of generic alprazolams made in the US), only TWO which would he considered even 'acceptable' to European consumers - Greenstone (owned by Pfizer and identical in every way to the branded XANAX tablets) & Qualitest's 'V2090' 2mg bar-shaoed tablet; not nearly as efficacious as the Greenstones, but at least acceptable, and equivalent to European Kela, maybe Teva - dependent on which facility they are made! - & "New Sandoz" - Sandoz USA's 'GG248/249' tablets are literally some of the poorest I have tried, and which are usually from India or Pakistan, as counterfeits, punch dies for the TDP-X series of tablet presses so beloved of counterfeiters being available for about $150 each; Watson ? 534 blue tablets and '853' punch dies are also commonly sold for those machines, and I have read so many posts from people who have bought 'hydrocodone' from that area at prices which seem impossibly low, being completely ignorant of the fact that the drug is not available outside the States, and there is not a single Web-based Pharmacy which ships from the US internationally AT ALL.
I have never yet come across a Mallinckrodt generic which is anything less than excellent, and they appear to make the finest generic opioids in the USA - a fact corroborated by the American Generics Association, who have voted their products best in the opioid class at least five times in the past ten years. The M367 hydrocodone/paracetamol are way ahead of any competition, only brand name Abbott VICODIN NEW HP 10/300mg white and Qualitest V3601 yellow being close to the same quality; the brand name tablet is far too expensive though (thanks to the self-regulation and endemic price-fixing in the American Pharma Industry) but would be my choice were they cheaper; not only myself, but the lady I often help out with a couple of days' worth of the Mallinckrodt won't consider any of the others at all!
Perhaps there is some bioavailability issues with the excipients used in Maloimckrodt's pills - though having checked them out, I see no obvious reason or substance there which would do such a thing, unlike the awful Auden clonazepam 2mg I have been dispensed since Roche withdrew their original Rivotril brand due to lack of sales (NHS 'dispense cheapest available generic' policy) forcing me to take either Roche's own originals from the Low Countries, or the cheaper - and in fact, BETTER - Galenika Roche-licenced Rivotril made in Serbia, along with Belgium, Netherlands, Hungary, Romania and Slovenia, where the highest quality medications in Europe are made and dispensed. (In Communist times, we would pay a relative fortune for benzodiazepines made in Romania, mostly by the State Pharma Company TERAPIA - meaning 'therapy' - and they were pretty much impossible to get hold of more than a few times annually, again from friends who were prescribed them. Hungary, Romania and Russia (Soviet Union as was) were renowned for their high quality and for being about the only countries one could purchase medazepam, a drug very similar to diazepam but with far less unwanted sedation, always a problem with diazepam even at low dosages.
Summing up my reply to Jennifer's original question, I can see no pharmacological reason for her side effects from Mallinckrodt 10/325mg hydrocodone/apap, and in my experience, their generic opiates are always amongst the finest one could possibly get in the US; their original brand temazepam 'Restoril', a powdered capsule - better than any tablet as binders are well known for inhibiting the body's take-up of temazepam, but nowhere even close to liquid concentrate-filled gelcaps (Normison brand, ex-Wyeth, now Pfizer or Aspen) or the unbeatable Oral solution 10mg/5mL, which contains absolutely nothing to prevent full oral bioavailability. AVOID PAKISTANI MADE NOVARTIS PK RESTORIL (which does not even hold a Mallinckrodt licence to use the brand name and which are roughly half the stated potency) WIDELY SOLD BY THE SAME KIND OF WEBSITE SELLING FAKE HYDRO, OXYCODONE, AND US-IMPRINT ALPRAZOLAM TABLETS! They have a brand called ALPROX which are a bright yellow and carry the Actavis/Purepac 'P039' imprint on a much rounder, thicker and brighter, almost electric yellow, 'bar'. You would be lucky to find one which contains any more than 1mg alprazolam!
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Queencharlotte Says:
My daughter works in pharmaceuticals and when I told her that Mallenkrdt did not work at all, she said that they all have a range... I never could tell that I had taken anything when I took them. She also said that the inert ingredients could have an effect on how they worked.
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amberlilly Says:
I know this is an old post but I was searching info on the generic norco made by Tris because it is new to me and has been causing severe stomach cramps. I've read that it is made in India. Anyway, I wanted to have the right information when I talk with my Pharmacist about the differences in the generics so I wanted to be able to give her legitimate source of information because I know she is going to say "you can't believe everything you read on the internet." But I have been taking Norco for 15 yrs so I have had many generics and they are definitely different. I was wondering how you've obtained your knowledge about the 40% difference. The other person talked about a 20% difference obtained infor from a manufacturing rep.
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amberlilly Says:
Supposedly the Oxy is stronger and most desirable, but for some reason it didn't work for me either. It made me sort of tired and sleepy, the hydro gives me a little boost. I read somewhere (did a search on it) that some people do not have an enzyme to process it. I changed back to the hydrocodone.
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Mommez Says:
Actually it's DEA & state Boards of Pharmacy who are monitoring all docs & their percribing of all addictive meds. Now docs have to be treating "conditions" & diagnosis has to go with it.
I also have heard more than one doc say flexeril addictive, NOT. They have gone way too far.
As recovery addict, I cannot get any pain relief from chronic pain. I've had several surgeries in recovery & was able to take pain mess as prescribed but doesn't matter. I am human being first & don't deserve to be punished by suffering in pain. Addicts are people too. due to my history I even have all the medical history but docs are intimated by BIG BROTHER WATCHING. also many docs have left pain medicine practices because of changes.
It sux all the way, fear it is gonna get worse instead of better.
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zaborav Says:
Mommez, the interference in medical, clinical matters by a LAW ENFORCEMENT agency simply would not be tolerated anywhere else (bar Greece and Turkey, where codeine is not OTC, in fact is scheduled the same as diamorphine - and there it is Sch 1, not Sch 2 - docs can not even prescribe it!) Recovering addict or not, there is plenty of evidence that when such patients are prescribed opioids for chronic pain, they do NOT return to their former ways; iatrogenic dependence is extremely rare, even amongst that group. I myself had problems which required residential care, but I am taking the opioids and benzodiazepines which USED to cause problems. The need for relief overrides any dependence issues, and I have over 10 years of experience in that; absolutely no cravings or wishes to raise my dosage above what is required to be pain free. Do not be afraid. If you have psychological issues about having to take something you previously had problems with, find an NA counsellor who is well versed in this and similar situations, and understands how recreational and iatrogenic usage/dependencies work. I am prescribed oxy, clonazepam and lorazepam with absolutely no problems. And fentanyl for rescue analgesia (intranasal spray, 125mcg/dose). Anybody else have experience in HAVING to use drugs which had previously been a problem?
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Trudy Says:
Tris Pharma hydrocodone contains no hydrocodone. Actually feel like I am being poisoned.
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Tahuehuehue335 Says:
My script of 7.5/325 was changed to Tris last month and I cannot even take them anymore. I've never had issues with hydrocodone in the 1.5 years I've had them prescribed after a failed hip surgery. I feel poisoned about 90 mins after taking them and my BP has gone up above my normal levels.
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BL Says:
Trudy, Prescriptions generics have ot contain a certain amount of active ingredients. If your prescription is for Hyrocodone 10. It has to contain 8-12 mg of Hydrocodone. Fillers and binders can affect how a drug is absorbed in your system. Some people have mild reactions to the fillers and binders.
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Taffy Says:
I had C115 imprint, 7.5/300 and there wasnt a drop of hydrocodone in tbeir worthless pills. Pissed!
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Taffy Says:
Tris hydrocodone imprint C115 worthless. Anyone else ever try these? You can take 5 of them and feel totally normal. Always had M360 and i only need 1 to work. Tris in my opinion makes fake meds.
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schmed Says:
Yep, I was switched from the yellow birds to Maliinkrodt (mallin-crock), and they suck. I complained to pharamacist and my neurologist,
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Mike Says:
I have been taking yellow 10/325 for ever. Went to Kroger they gave me the white one in so much pain they Don't work know have a swollen throat hurts like all get out this not right. Mallinckrodt should be fined jailed put out buisness
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Kimber Says:
Try to avoid the Amneal generic for Norco. It is pure garbage!! It's made in India so they don't have the codes they enforce in the US. The 10/325 made me feel like a zombie. Pure garbage!! I'm sick of these companies cutting corners on painkillers!! We suffer for it!! These generics are s***!!
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Milos Mom Says:
Re: Steve (# 57) 
Depending on where you live, Smith's Food & Drug sells Mallinckrodt in Albuquerque. They are tied to Kroger, so it's worth calling them to find out if they do.
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mr pissed off Says:
Mallinckrodt pain pills are a joke; worthless. How they stay in business, I don't know. Someone at the Mallinckrodt plant must be taking hydrocodone out the back door, as it damn ain't going into the pills... Unless you want to puke or have a bowel movement, don't take one! How do we file a legal suit against Mallinckrodt? It is bad enough to have back pain, I don't need stomach pain too!
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Linda Says:
Does anyone know why Kaiser Permanente has switched from giving patients Qualitest Norco to the Mallinckrodt brand?
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