How Long Does It Take To Get Oxaliplatin Out Of Your System?

On Oxaliplatin for four cycles still have the cold reactions and was wanting to find out how long it stays in your body?

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How long does it take to get Oxaliplatin and xeloda out of your system?

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Oxaliplatin has a short elimination half-life of about 10-25 minutes. Many pharmacists consider most or all of the drug to be out your system in the period of about 5 half-lives. In relation to this drug, that would mean Oxaliplatin takes roughly 2 hours to leave your system.

Xeloda (Capecitabine) is largely eliminated as metabolites (> 95% of the dose). The terminal half-life of the parent drug and its metabolites is short (less than 1 hour), and excretion proceeds via the urine. Essentially this would mean that Xeloda should be out of your system for the most part within a 4-5 hour time frame, depending on each individual.

NOTE: the average time it takes to leave your system is largely dependent upon the amount of each drug taken. The half-life serves as a general guideline and should be re-calculated according to the dose taken (for more accurate results). In either case, 5 half lives still provides a good estimate.

To do the math, simply divide the dose you took (e.g. 20mg) in half after the half-life period is over (e.g. 10 mg), and so forth until you have a small number. I recommend using a calculator for this method.

Do you have any other questions or concerns regarding these drugs?

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