Harvoni Side Effects

I have been taking Harvoni for 3 months now and am having nerve pain in my legs and lower back pain. Is anyone else taking Harvoni having any of these same side effects as me? Please help if you are able. Thank you

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Hi Tony,

From what I've researched, "lower back pain" is specifically listed as one of the more common side effects of Sofosbuvir (the second active ingredient in Harvoni); so I'd imagine that "leg pain" may be attributed to this drug as well.

If you'd like a more concrete reference, "back pain" is also listed as a side effect of Sofosbuvir on Pubmed at:
ncbi.nlm.nih.gov/pubmed/25422576

That said, you may want to contact your doctor if the pain becomes too bothersome or severe. This way you and your doctor can determine if Harvoni is still right for you.

I hope this helps!

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Very helpful Thank you so much. The doctors all tell me the same thing "Keep Taking It or it will come back the hepC." No matter what I tell them they all want me to stay on .

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Hello Tony. Yes, I have been having knee pain and swollen right knee, as well as back pain. I am currently at week 11, of 12 week treatment. I was told but the treatment team, that this was not a reported side effect. Glad to hear that I am not the only one. Thanks...

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I have been having a lot of nerve pain in my legs as well as my arms and had wondered if it was Harvoni related. I am in week 10 of treatment. I'm glad to know that this is probably a side effect.

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I recently was approved to start using Harvoni. The Dr. has never told me what my viral counts are and they say I may experience some headaches & some heartburn. After reading some posts from Harvoni patients, I see its a little more than just that.Do I have some fears that other side effects will occur....... yes. I dont feel I can handle more set backs, my energy is low & pain level is about a 6-7........You see I'm in my 2nd. mo. of re-cooperating from cancer surgery and dealing with a colostomy & 2 deep muscle flaps in my butt.

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JoeP, I am very sorry to hear all that you are going through. It is hard to advise you one way or the other on Harvoni given your situation. I can only tell you from my own experience that the side effects have been sporadic and have never been so bad that I didn't feel like I could continue on with treatment. Everybody is different, so I don't know if that is the case with other people or not. Personally I had more energy for the first six weeks or so, but I think the insomnia has caught up with me and made me more tired here at the end of treatment. I only have one more week, so I definitely feel like any side effects I have been through have been worth the result. Hope this helps!

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I am in week eight, only four weeks to go. The headaches are almost daily, as is the nausea which was stated in all I read. I have been having some real back pain but I have had back issues in the past so not sure what the story is on that one. For me there is no turning back, I will complete the last four weeks regardless of side effects. The back pain is in my lower back on the left side and it is a bit debilitating at times. This is first I have heard about back pain being a side effect. It got so bad I went to the emergency room and I have to be hurting to go there. The pain radiates (at times) into my left testicle, again strange. If it is a side effect I can deal with it, the other option is not really an option.

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dear Charity............ Thank you for your input in which I truly respect. I waited this long to respond because I wanted to wait until I heard from staff on my decision (it only took 3 business days to hear back) amazing.......... But anyway I told them I am not ready to take any kind of issues associated with this medicine until I feel 90% healed from my operation, I cant handle more setbacks @ this time.

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Tony........I just finished my 12 weeks yesterday but, for the last 4 or 5 weeks my legs have been aching really bad, especially when I walk. I have had no problems with my legs ever, so it will be interesting to see if the aching goes away now that I'm finished with the Harvoni.

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Same here. I completed my harvoni. Now have severe pain in left knee and my back. Have to walk with walker now.

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Yes! The pain in legs, back is horrible..Nothing works.

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I took Harvoni for the 12 week program with no side effects and the virus is undetected. The doctor follows up with blood tests for quite awhile. I just hope it stays undetected. I too got nerve pains in my legs after the Harvoni. I took my last pill on the 24th of May. I went to a Vascular doctor because I didn't know what the problem was. He said my veins were fine. I suspected the Harvoni and now that I hear someone else complaining of the same problem, I'm thinking maybe it IS the Harvoni. My legs are getting a little bit better the last 3 or 4 days, so I hope it goes away. Maybe yours will too.

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i'm sorry to hear about all the discomfort you are going through. i finished my medication almost two weeks ago. I've been having the most severe lower back pain and it is in goes down into my groins. Like you i've had a history of back pain so i'm used to it. But this is just terrible. Going to the chiropractor doesn't help except for a short time. anti inflammatories help but not for long. It's piecing debilitating pain like i've never had before. I think of going to the emergency clinic it's so bad..but i just keep thinking that it will get better.I keep think that if i just stay as reasonably active as i can it will get better. i hope your're better by now! and everyone who has suffered side effects will get over them quickly.

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Does anyone know if the back and leg pain or any of the other negative side effects go away? I've been off meds for about 10 days but still have them.

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Take Harvoni at night before bed and have 2 bottles of water by your side. Make sure you drink the water during the night and use the bathroom. The morning will feel tired but as day progresses you will feel much better. When you feel flush or weak drink water.

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thanks so much! this is new territory so it is nice to get some good ideas!

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I finished an 8 week course of Harvoni last day in March. Prior to treatment I did research the 2 products, especially carcinogenic studies. One of the ingredients is still "being tested" which spelled trouble to me but I had waited 35 years for a treatment and needed to do something. All pre treatment sonograms, etc showed absolutely no liver damage, unremarkable gallbladder and pancreas .2 months post treatment showed sludge in my gallbladder ( I'm a vegan) and 3 months post treatment I now have a gallbladder cyst that is a precursor to biliary Cancer. The drugs are metabolized by Bilary system and pancreas , kidneys and gallbladder are all being impaired!! Be leary, I am starting to feel that Cancer of the biliary system could be a side effect of treatment. I will keep you updated...

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It goes away about a month to month in a half later

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No it doesn't. I think it depends on person. I've been thru with meds since February. Unfortunately, I now walk with a walker, when I can walk. I can barely stand longer than a half hour and no I did not have trouble before.

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Stef........are you saying that Harvoni has caused you to not be able to walk?

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Does anyone else have puffy to tingling feet after taking Harvoni or Epclusa?

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I need to find medical consultant who will work with my case

I am not asking for members to help me find a particular doctor, rather I am asking for members to help me locate medical consultants that in turn will help me find the right doctor for my son.

1. Age 42, male, height- 55, weight-143,3 lbs., non-smoker, living in Texas.

2. As far as symptoms, they are due to medical treatment that was for childhood Hepatitis C, as in all symptoms began during treatment and now remain (excessive exhaustion, severe brain fog, constant lightheadedness, memory issues, photophobia), although Hepatitis C is no more after treatment.

3. Treatment began in 2016. He was treated for 3 months with Harvoni.

We have seen a few doctors for the issue, they have ruled out autoimmune, and MRI showed to be normal (as per doctors), and after they rule certain things out they simply let us go, that is why we are asking for a Professional Consultants who can advise which specialized doctors are because doctors just dropped the case, so Professional Consultants who will take the case and will lead the case with the goal of actually helping us take the case to a certain completion.

THE DIAGNOSIS OF MY SON HAS NOT BEEN ESTABLISHED SINCE 2016!!!

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Re: Becca (# 82)

i started taking harvoni 3 wks later hospitalized w septis 5 days, never ascertained the cause everyone said it couldnt be the harvoni-i think it was-no other logical conclusion

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Re: Von (# 713)

David! I was reading that drug named Lyrica is for nerve pain. Read about it on Internet. Maybe your family Dr. will give you prescribtion for it. Good luck with treatment.

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Re: David (# 1)

I have nuropathy in both legs, feet and hands. I garden for a hobby. My legs tingle, go numb and my feet feel like I'm walking on lava hot gravel. One day I was inn the garden and didn't relize I was standing on a red ant mound. That's how much my legs hurt. For months I'd complained about my vacume cleaner not working. It was working fine it was my nuropathy. I thought there was sand still in the carpet. I was going crazy cleaning the carpet all the time. I wish there was a cure for just the nuropathy. They have drugs for the pain but I'm not taking a general purpose drug ie: anti-depressants for leg pain and I'll be damned I'll not take a narcotic for it eitger... oh well im just stuck.

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Re: Von (# 711)

I took it in 2016 and also got peripheral neuropathy in my feet as a side effect from harvoni. The doctors just gave me gabapentin which does nothing for the nerve pain relief so I know how it feels. I blame the FDA for fast tracking it so the government would get off their back to find a cure for hepatitis c

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My name is Karen. I took Harvoni with interferon because my geno
Is 3b. I only took it for 9 days 2 years ago and I have nuropathy (nerve damage). My nerve damage is so bad I had to give up wearing socks. It keeps me awake at night many nights. I won't take pain killers because they make me vomit. Other medications to relive my pain only make me feel wierd and don't really work for my nuropathty. Nothing works because the medication was not made specifally for nuropathy. There is no cure. I'll will catch up with you all at a latervdate. My legs are freaking out right now. I can't sit still it hurts so bad. I also have it in my hands. I only took the Harvoni for 10 days and I have a world of side effects

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A law firm that is interested in those injured by Harvoni, Sovaldi or Veikrira. Give Fleming Law out of Texas a call or do it online:

fleming-law.com/blog/2017/november/drug-induced-injuries-from-harvoni-sovaldi-and-v

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Re: Jsda (# 707)

Try cramp defense magnesium bought online, it helped with cramps. Keep us posted. Many of us are in terrible shape.

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Re: Jsda (# 707)

Your GI will NEVER admit these symptoms as Harvoni related, the best you can hope for is a very good PCP who will take you seriously. Your symptoms are the same as so many others, like myself, one thing is for sure that may help and has helped me is Cramp Defense magnesium, It is the only brand that helped relieve my muscle cramps that are debilitating. Also be aware of any other side effects you have from harvoni, report them all the Gilead and the FDA. Please keep us posted as you progress, I am 2 years post and my back pain increased 100%, many of us are now unable to work due to the side effects. I hope you don't have the same damage as some of us. Good luck and please keep writing on here.

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