Grapefruit Juice And Opioids (Page 2)

So I just took my dose of liquid methadone and drank 3 cups of Grapefruit juice. A couple hrs later I pretty much blacked out on and off for a few hours. Has anyone else have this happen to them? Also I'm about to take my daily 60- 80mgs of oxymorphone ER. If I drink another couple cups of Grapefruit juice is that gonna happen to me again or does it only pertain to Methadone? Any and all info is appreciated thank you

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Grapefruit juice is a big no no for Methadone and other Opoids. I was on the high dose Methadone program in Sweden for years. During the 1st 3 months all of us had to go to the clinic and submit a urine specimen in front of the women workers (one faces you through a hole in the wall at the bowl level and another stands next to you). Everyday a new expert would give an hour long lecture. One guy came to tell us what food to avoid. Hamburger buns with seeds can leave a positive response for morphine as they send them to labs. Grapefruit juice apparently is different in it's make up to nearly all other fruits. It's very acidic and Opoids are strong alkalines. The grapefruit juice stops the Methadone working causing adverse effects. Partly abstinence. So drinking a litre of my favourite juice is history. And has been since 1984.

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I am really skeptical that you are actually taking 80mg of Oxymorphone and taking 110mg of Methadone....There's no doctor that would get away with prescribing you this amount of medication.

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Re: Chris (# 22)

I would never prescribe my patients Methadone and Oxymorphone for pain....In my professional opinion it's way too high of a dose number 1 and number 2 I am pretty liberal with prescribing pain medicine....I would never prescribe these 2 drugs together simply because they both depress the respiratory system way too much when taken together or even separate. There are other long-acting and short-acting opiates that work better together than this combination......

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Re: Cher (# 13)

Exactly ?? right......Also let me just say........Even when I prescribe legitimate doses of pain medicine to people with legitimate pain Acute and Chronic pain.....The pharmacy is always calling me or texting me questions.....Like are you sure this patient is having severe enough pain to prescribe them Dilaudid or Oxycodone.......So it's beyond my comprehension for this guy to be getting extremely high doses of Methadone and Oxymorphone and no pharmacy or pharmacist has said no.......Absolutely not. Just saying ??

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You're all mostly daft. Only white grapefruit juice nonconcentrated has the enzyme to change mainly benzo potentiation.

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Re: GmanzA1day (# 25)

Where did you get that idea from? Please share an article stating as much. This is what the FDA says on it:

https://www.fda.gov/consumers/consumer-updates/grapefruit-juice-and-some-drugs-dont-mix

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Re: cliff j (# 11)

Sorry, I may be naive because I've been on methadone 51 years but can someone explain to me why grapefruit juice does that? I'll be 71 and not looking to get messed up. On monthlies and take 120 ml a day as prescribed.

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