Eliquis And Weight: I Need The Truth


Today I am speaking with my hemotologist about switching from Xarelto to Eliquis. Xarelto has caused me, a runner with a very slim diet, to gain almost 14 pounds in 4 weeks. 7 of those pounds in the last two weeks.

I need to know of any serious weight gain issues with Eliquis. Doctors always swear that the side effects listed are the only ones but I was never told by my doctor nor the literature that Xarelto causes abnormal weight gain either. Google had to tell me that after yesterday's terrible weigh-in. I'm looking for absolute candor. I am 34 and female and I'd be taking it for PE.


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Anytime you want to know all possible side effects, it's best to ask a pharmacist, visit a site like this, or research it on your own. Doctor's aren't trained as much in medications, so unfortunately, they usually only know the very basic most common ones for any given medication.

Now, as to the Eliquis, it usually causes decreased appetite, in most people that take it, so weight gain isn't listed.

Its typical side effects may possibly include nausea, headache, increased risk of bleeding, anemia and hypotension.

Is there anything else I can help with?

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I also wanted to add that there is no way to know how any given person will react to any given medication, so there is still a chance you may gain weight, but it's not something normally expected, as listed by the FDA.

Are there any other side effects you'd like to know more about?

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That's all I wanted to know. As an update, I took OTC diuretics and in 3 days I was back at my normal weight but since I don't want to have to do that for the course of this treatment and since Xarelto has also caused serious palpitations and chest pains, I'm still going to switch to Eliquis.


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You're very welcome! Please post back and keep me updated!

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Xarelto made me very very sick and I switched to Eliquis with no side effects and in fact I lost weight being on it unless it was the fact that I felt so much better and was more active..Either way I feel much better

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I'm on 5mg eliquis and I'm not able to eat much at all I've lost about 35 poumds. Is there anything I can take to keep weight on???

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My husband has begun taking Eliquis he has lost 16 lbs in 3 months and also urinates a lot he has an appointment with his doctor in a week. He does not like the overall way he feels.

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Should I be concerned about loss of appetite while taking Eliquis

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I'm on Eliquis 5 mgs twice a day. In the last few days I have switched myself to 2.5 mgs twice a day. I'm extremely fatigued. I was on Eliquis for 3 months because of a provoked dvt in my leg last July and then I came off of it in October per my PCP. I have no energy; my PCP doesn't believe me. I know it is the Eliquis. What else can I take? I'm having to drag myself through the day. Even if I sleep 12 or 13 hours I'm still tired and would continue sleeping if my husband doesn't make me get up. Feeling discouraged and depressed.

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Hi. I am working out 90 minutes a day 5 days a week. I have always watched my diet and concentrated on the right foods for triathlon etc. I am always between 179-183. 183 I would consider the point when I put on the brakes and refocus on diet. Usually the end of summer coming off 2 months of beach and bbq. Now since on Eliquis, I have shot up 10 pounds. I have reduced my calories, continued working out. I rarely drop below 190. It is frustrating. Dr said it slows the metabolism.

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I have been on Eliquis 7 weeks and have gained 7 pounds!!!!
I see your post is old but if you see this I am wondering about your experience if you switched to it...

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I'm having similar problems to Bruce. I started with Eliquis in November because of a blood clot in a lung (which caused an inflammation). I stayed off the training for 2 months to let the inflammation heal (until the middle of January). During this time nothing happened to my weight, which is to be expected, since I probably ate a bit less than when I hit the gym 5 times a week. I stayed at a solid 97Kg (213-214lbs).

I usually have no problem maintaining my weight at a diet of 3000-3500 Calories. This did not change with Eliquis.
However, at the end of January i started my yearly cut (I've done quite a few of these before). I dropped to 2800 Calories for a week, the weight didn't budge. My thought was; "Strange... Oh well, guess I'll drop it down a bit". I dropped to 2600 Calories for a week, the weight didn't budge. I started to get suspicious, but thought I might just have retained water. I dropped to 2400 Calories for a week, the weight didn't budge. I now realized something is not as it should. Eliquis? I dropped to 2200 Calories for a week, the weight didn't budge. I see some more contours and stuff in the mirror, but the weight is the same. I am now on my second week of 2200 Calories and still weigh the same. Normally I might be at 2400-2500 after 4 weeks. This result feels so improbable and unlike how my body has reacted to cutting before.

With the above adjustments I should have lost up to around 3Kg (6.5lbs). I don't feel bloated, fatigue, loss of appetite or anything like that. There has been no weight gain for me. But the weight loss seems impossible. I'm 30 years old and feel that this is weird. Is there any way for Eliquis to make me retain as much weight in water as I lose in fat? I have a doctors appointment in May again. Maybe I'll get some clarification then.

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I totally agree. I switched to eliquis today for the same reasons. I gained a lot of weight on xarelto, felt fatigued and had chest pains. My gums started to also bleed.

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I've been on Eliquis for about 8 weeks and have lost 12 lbs in that period of time, even wit a cruise thrown in. I've been trying to lose, so I don't think it has has an adverse effect on my efforts. I had some indigestion the 1st week and then no other side effects. I have more energy, which could be attributed to many things including weight loss, PE has cleared up, exercise and started using a CPAP for sleep apnea.
My only problem is I think I have developed another DVT in my leg. Will know more tomorrow. I take 5mg twice daily.

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Joe, I've being having the same problem for a few years now. I cannot lose weight and I watch my diet and workout 5 times a week. Ive been taking this medication for about 2 years and have gradually add weight for no reason...but cant take it off...no matter what I do.

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Update. I do not have a DVT in my left leg. The swelling and soreness is actually due to exercise. I'm continuing to lose weight, which is my goal.

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I have been on Eliqus 7 months now after having a Pe and I've gained at least 2 to 3 lbs per month while on Eliqus, my doctor says it's because I'm not as active as I was prior to the Pe, I think it's because of the Eliqus...

Concerned and overweight

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My name is Rhonda and I had a PE In August and was put on Eliqus and have been gaining weight and cannot get it off even counting calories, waking and watching my diet, I too think it's the Eliqus and once gaining it's hard to not gain while on Eliqus.

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I have develops right back pain and a sharp stabbing pain around you front. Have a liver ultra sound and gallbladder all was well. Could eliguos cause this.

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I cannot lose 1 pound since I started on Eliquis. I am very tired most of the day. I took a water pill for 2 days and still no weight loss.

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Re: Rebecca (# 95) Expand Referenced Message

Rebecca Yes!! My urine and bowel movements smelled like tainted meat. I’m not sure how Eliquis caused such a foul odor or why my body had such a bad reaction to it. Must have something to do with the way it alters the blood. This was just one of many painful side effects l experienced. Thankfully I’m no longer taking Eliquis.

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I've been on Eliquis for 4 years now & have not experienced any weight gain. I did just recently begin to experience some minor depression but so far I am able to manage it.

I agree with another post - do your own research - when you ask pharmacists make sure they look in all levels of side effects, from common to rare (they are classed that way in their PDR)
PS Thanks for the info about Xarelto - I'll be sure to steer clear of it.

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Re: Megan (# 6) Expand Referenced Message

I'm dropping weight also. I eat more greens and fruit. I take Eliquis and Ferrous. I also go to physical therapy. I'm plus size but this medicine have me dropping weight.

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I have suffered some of the worst side effects ever while using eliquis. Take the weight gain, it’s better than joint pain, dizziness, fatigue. Good luck

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Re: Rebecca (# 95) Expand Referenced Message

I noticed that. I drink a lot of water. I wasn't sure what was going on.

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Got almost 40’pds off me & my
Husband beck in early 2019 with low
Carb/keto ,we both felt absolutely
Amazing. And then stick to a healthy low carb lifestyle. As well walking about 4 to 6 miles a day .

BUT , by the end of 2019 into 2020 found out I have an estranged brother through dna testing and found out quickly they battled addiction , which rattled my
Nerves . Then, the pandemic hit, and that really rattled my
Nerves . So I was a bundle of
Nerves so bad, I had an AFib issue & ended up in the ER .

After that first episode ,Instead of just adjusting my metoprolol I was already taking , they added Eliquis, and “yep” , gained back all that weight I lost and then some!

Physically , I cannot lose it. It’s got me so depressed, and stress is my
AFib culprit,

No matter what I say to my
Cardiologist, she argues it .

I even called the maker of Eliquis & told them how many people are gaining weight , they I assume are getting phone calls but due to privacy wouldn’t tell me of true or not ? , which is not good for anyone’ to gain more than 30+ pds , Let
alone someone who has high stress levels & can have AFib episodes.

I feel like a huge balloon, my stomach is swollen , my left leg swells all the time now and I’m flat out miserable.

Last phone convo with my cardio she said I had to take something because I’ve had a few AFib Moments & offered Xelatro to try , which I haven’t done because I don’t want to be on any of them at all !

There are steroidal properties in Eliquis, which can make you
Gain weight let alone increase of appetite.

I seriously suggest anyone to call the company on your Eliquis bottle and complain about the weight gain, it’s just not good for anyone to be gaining too much weight, let Alone from their product, and needs to be Added to the side effects For Eliquis!

I see my cardio in person tomorrow, sure she will give me static about not wanting to Take any of this crap .

Anyone also have odd fevers or hot moments from it btw ???

(It Could be that I’m a heffer now carrying all this extra weight) ??

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I have gained a ton of weight on eliquis.

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Re: Verwon (# 1) Expand Referenced Message

Does Eliquis cause your urine to have a bad odor?

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Re: Lexie (# 93) Expand Referenced Message

As my one doctor told me when I had breathing issues my cardiologist didn’t believe me. He said only the patient knows. It’s your body. I did well on Xaralto.

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I had to start Eliquis in 2016. Not longer after I started I immediately gained 20 pounds. That was with eating the same as I always did with no change. I seem to keep putting it on and when I tell my Doctors, I feel like they think I am lying. I eat healthy, stay away from fast food and fried food, sweets etc. it does not matter, but they say this is not a side effect. Tell that to my body after I have gained 40 lbs. I have to be on it too.

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