Does Prednisone Affect Methadone?
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I'm to start prednisone 20 mg today and go down. Now I'm on 40 mg methadone. Should I spread it out cause I'm seeing different posts about it messing with the methadone. I won't get sick will I?

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Re: Verwon (# 1) Expand Referenced Message

How do you know this?

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I thank you for getting back to me. I have not had any problems with the two except headache and some diarrhea but that's gone.

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Hello, Julie! How are you?

Yes, Prednisone may reduce the efficacy of your Methadone, so you may experience some withdrawal effects, according to the FDA, they may include nausea, dizziness, headache, diarrhea and rebound pain.

Separating them by a few hours might help, but isn't likely to change much.

Is there anything else I can help with?

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