Difference In Effects Between Medications (Top voted first)

I had been taking Hydrocodone 5-500 (Vicodin) many years at the same dose when this drug was discontinued an replaced with the 5-325 (Norco) strength. I am still taking the same number of pills daily but after about three months I just do not feel like the new pills control the pain as well as the previous ones did. I know there is not supposed to be any different between the two other than the amount of acetaminophen is there anything else that might effect how the medicine is absorbed and how quickly it is? Any ideas would be appreciated, thx.

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Hello, Jerry! How are you?

The Acetaminophen actually potentiates the action of the narcotic, so when the amount of it is lowered, it can cause the medication to be less effective for you.

This is a narcotic analgesic, so it has the potential to be habit forming and may cause side effects, such as nausea, dizziness, drowsiness, dry mouth and constipation.

Is there anything else I can help with?

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Jerry, when you have a heneric, the amount of active ingredient may vary, the fillers also vary and this can make one slightly stronger or weaker than the other. If you have a generic that has 10 mg of a med, the actual amount may be 8 mg-12 mg. If they have been making the med with a higher level and then they switch to the lower, that may explain why it isn't as effective. Also the fillers may affect absorption. Try taking one regular strength tylenol (325 mg) when you take the Norco and see if you notice any difference. I don't think it will make much difference, but I may be wrong

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Thank you, I was not aware that such a seemingly small change in the amount of Acetaminophen could make a significant difference in how effective the medication is. I will try making up the difference to see if that helps. And yes I am very aware of the side effects but it works to control the pain and there are no better options I am aware of.
Again thanks.

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