Contrave And Use Of Opioids For Pain

How long do I need to be off Contrave prior to having a significant orthopedic procedure which I know I will need opioid pain meds for after?

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Hi Cherlyn,

The half life of Contrave's active ingredient 'Naltrexone' and its metabolite (naltrexol) are reported to be about 4 hours and 13 min. However for the simplicity of keeping track of time, I'd probably just average it at 4 hours. And you'd probably want to double check with your doctor/surgeon on this - but I've heard from some medical professionals that it can take up to 3-5 half lives for a medication to leave your system. IF this really is the case (and I know everyone is different), 5 half-lives for Naltrexone would add up to 20 hours (or pretty much a full a day). 4 hours is a relatively quick half-life compared to some other drugs like Suboxone, which reportedly averages around 36 hours. So depending on when your procedure is taking place, it sounds like you wouldn't need much time in between Contrave and pain meds.

Please note once more that this is just my perspective and you should always consult your doctor before making any changes to your prescription.

Hope this helps!

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I have been on Contrave for a month. I was prescribed Percocet yesterday in the ED for extreme pain from what they found to be an 8 cm mass in my ovary. How long do I need to be off of Contrave for it to work? Also, will I need to titrate up again or just resume Contrave with my current dose of 2 tabs BID?

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