David Says:
Carb / Levo Er 50 200 Tab Half Life And Absorption Rate
Updated
Jim C Says:
what is the effective half life and absorption rate expected for carb/levo extended release 50/200 mg tab mylan?
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1
Elimination half-life of levodopa in the presence of carbidopa is about 1.5 hours. Following Carbidopa and Levodopa extended-release, the apparent half-life of levodopa may be prolonged because of continuous absorption.
The extended-release formulation releases levodopa and carbidopa over a 4-6 hour period. I'm not quite sure what this equates to in terms of half life. But to be safe I would estimate the half-life to last an extra couple hours.
As far as absorption rate goes, the extended release tabs have a bioavailability rate of 0.70 to 0.75. The approx. amount of bioavailable Levodopa in each tab is 140 to 150mg out of the 200mg pill.
I hope this helps!
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