Can Steroids Cause Fentanyl Medication To Wear Off Faster?
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I've been using 100mcg patch Fentanyl every 48 hours for months now. Last week my neurologist had to prescribe me a Medrol-Dos Pak (steroids) because the pain in my knee became unbearable, even with pain medication. It was too early to get another shot. So, I'm now on DAY 3 of the DOSE PAK, and I swear these patches start wearing off after only 1 day!

Out of the blue I started feeling horrible withdrawal symptoms yesterday, even though I wasn't due to change the patch until today. I had no choice but to replace the patch early. I figured maybe it was a defective patch. But now TODAY I am experiencing the same problem. If these are not defective patches, then the only factor possible is the steroid medication having an effect on the medication/or my body's tolerance level. ??? Does anyone know anything about this?

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No, I have been on the patch for ten plus years now and I have had the steroid pack numerous times and I have also has dozens of steroid trigger point injections ,and I have also had steroid epidural so ,surgery version and Asia for the mass amount of steroids making me a raving loon,it has absolutely no influence on my patch which I change every 48 hours ,what you want to watch for is if your doing any mass sweating and have had a higher increase in body temps,because that wil force your fentanyl patch to accelerate and you will be way boucncier for sometime and fall down shorter than you need to as afar the 48 hour period ,only 20 percent of the population will need the patch on 48 hour span versus 3 day use,but I was one of the ones, there are times I have seem to be withdrawing,but I'm not sure it's that a much as I may have had a burst of fentanyl and then the ride down to normal is rather horrible,so to be super safe ,keep that patch out of the heat ,and if you go out make sure you wear layers of clothing ,to block direct heat, so far I'm ten plus years and never been to sickly ,and neve had any patches be. Faulty, you can look up the manufacturer and see if there has been any recalls , once in a great while you will catch that happening , I recently switched to the apotect brand ,something like that,veyy similar to Mylar,they are more flexible and don't fell like I'm wearing a interrupted patch ,plus no skin rashes, hope this helps ,sorry your having problems, for me I have no other choice than the patch ,life's to miserably any other way ,

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"They may actually be due to the Medrol. The FDA classifies it as steroid and it can cause some symptoms that you may mistake for withdrawals, such as nausea, insomnia, nervousness, elevated heart rate, elevated blood pressure, headache, vomiting and fever."

Thank you for your reply, but I'm not so sure that's it. I feel more intense pain, thought my knee feels better. But now my pinched sciatic nerve is much worse, and i feel very agitated and like I'm ready to come out of my skin. It's as if the patches are no longer adequate for the pain, when they were doing just fine before I started taking the Medrol. I honestly believe the Medrol is interfering with the function of the Fentanyl in my system.

I just changed the patch again today, and already tonight I'm ready to jump out of my skin and hurting horribly bad. This isn't right. It's either the Medrol, or i got a bad batch of patches from Mylan.

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Hello, dnVest! How are you doing? I'm sorry that you're so miserable.

What specific symptoms are you experiencing?

They may actually be due to the Medrol. The FDA classifies it as steroid and it can cause some symptoms that you may mistake for withdrawals, such as nausea, insomnia, nervousness, elevated heart rate, elevated blood pressure, headache, vomiting and fever.

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