Can I Take Amitriptyline With Methotrexate
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Can i take amitriptyline with methotrexate and prednisone?

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I take both drugs, I have 10mg of Amitriptyline at night and 20mgs of Methotrexate per week. I am not on th pred anymore but I experince no problems and it was the Rheumatologist that prescribed both drugs.

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can I take amitriptyline to help me sleep while taking methotrexate

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Based on my findings there is an interaction between methotrexate and prednisone. This interaction states the following:

"MONITOR: Although they are often used together in clinical practice, limited data suggest that corticosteroids may increase the risk of methotrexate toxicity. Individual cases of severe and fatal bone marrow suppression and fatal systemic moniliasis have been reported. Data have been conflicting. A pediatric study found no increased methotrexate toxicity; however, hepatic enzyme elevations were noted. The mechanism is unknown.

MANAGEMENT: Close monitoring for signs and symptoms of bone marrow suppression and nephrotoxicity is advisable during concomitant administration. Patients should be advised to report possible symptoms of toxicity including nausea, vomiting, diarrhea, stomatitis, sore throat, chills, fever, rash, unusual bruising or bleeding, jaundice, dark urine, swelling of the extremities, or shortness of breath to their physician."

Other than that, these drugs appear to be fine to take together. I hope this info helps!

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