Actual Amount Of Lorazepam

I was originally taking .5 mg of lorazepam (manufactured by Mylan) sublingually twice a day with great results.
My latest prescription is manufactured by Sandoz & comes in a smaller size pill. It seems to be less effective than the one made by Mylan.
Where can I find a comparison of the actual amounts of lorazepam used by different manufacturers? I understand Activas/Watson also puts one out as well. I read that companies can stay within 20% + or - of the original & still be considered as an acceptable.generic. How is that possible since the amount of active ingredient would vary?

REPLY

REPORT

1 Reply

What you're talking about is the Hatch-Waxman Act of 1984.

Ref: Hatch-Waxman Letters

Basically, in an effort to bring generics to market faster to help underinsured, or non-insured consumers, some requirements were eased to give manufacturers some leeway, and yes, that includes an allowable difference of plus, or minus 20% of the active ingredient. The FDA considers this an acceptable therapeutic window, because in most cases, 20% of the given milligrams isn't a significant amount.

Unfortunately, some people are very sensitive to any changes in their dosing, and they may experience unusual side effects when taking a slightly more potent generic, or they may find their medication to suddenly be ineffective, when taking a slightly less potent generic.

Unfortunately, the measurements aren't always made public, and the only thing you can do is try what your pharmacy has provided, and see how it works for you.

Alternatively, you could speak to your doctor about only using a name brand to avoid the discrepancies.

Are you on any other medications?

REPLY

Was this helpful? 0

I am currently taking 50mg of Zoloft and .5-1mg of lorazepam a day. I have been having bad insomnia, so can I take the 5...

1 REPLY

Are the 18 month old 1 mg pills of lorazepam fully effective? Or likely to be? Thank you. ## Hello, Steph! How are you? ...

2 REPLIES

I’ve been on 1-1 1/2 mg of Lorazepam for about a year and a half. I'm tying to taper off and looking for a saf...

5 REPLIES

Please show me photos of a round pink pill with the markings M 32. ## A round, pink tablet with M over 32 is manufacture...

2 REPLIES

Picked up my prescription of lorazepam SL 0.5mg Used to take this before this looks different to me. Very tiny light blu...

1 REPLY

Circled white pill with the letters Gg 93 no marking on the back ## I cannot post a picture due to copyright reasons, ho...

1 REPLY

What miligram lorazepam are small white and scored on one side and have R 59 on the other ## Hello, Weesha! How are you?...

1 REPLY

Can this medication cause negative side affects after only 3 days of usuage? ## After 3 days, I highly highly doubt you ...

3 REPLIES

Can I take two 0.5 mg lorazepam pills to make a single 1 mg dose if they are different brands? ## Hi Amanda! U can, if i...

2 REPLIES

I've been taking the form of lorazepam identified by a "v" on one side and "4008" on the other for y...

1 REPLY