Abilify And Parkinsons (Top voted first)

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My mother has Parkinson's (we think) was on Sinimet and Carbadopaleva and they took her off of that and now put her on Abilify and Ultram and now she can't talk suddenly and cries and is suicidal. For 3 years we have felt she's been overdrugged. Her mind is OK until they pump more drugs in her.

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1

Low Dose Abilify increases dopamine and increases mood. High dose abilify blocks dopamine. It sounds like the doctor needs to reconsider the dose ASAP. See Below:

How Abilify works:

Burris KD, Molski TF, Xu C, Ryan E, Tottori K, Kikuchi T, Yocca FD, Molinoff PB.
Aripiprazole, a novel antipsychotic, is a high-affinity partial agonist at human dopamine D2 receptors.
J Pharmacol Exp Ther 2002 Jul;302(1):381-9
Aripiprazole is the first next-generation atypical antipsychotic with a mechanism of action that differs from currently marketed typical and atypical antipsychotics. Aripiprazole displays properties of an agonist and antagonist in animal models of dopaminergic hypoactivity and hyperactivity, respectively. This study examined the interactions of aripiprazole with a single population of human D2 receptors to clarify further its pharmacologic properties. In membranes prepared from Chinese hamster ovary cells that express recombinant D2L receptors, aripiprazole bound with high affinity to both the G protein-coupled and uncoupled states of receptors. Aripiprazole potently activated D2 receptor-mediated inhibition of cAMP accumulation. Partial receptor inactivation using the alkylating agent N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) significantly reduced the maximum effect of aripiprazole on inhibition of cAMP accumulation. This effect was seen with concentrations of EEDQ that did not alter the maximal inhibitory effect of dopamine. Consistent with the expected effects of a partial agonist, increasing concentrations of aripiprazole blocked the action of dopamine with maximal blockade equal to the agonist effect of aripiprazole alone. The efficacy of aripiprazole relative to that of dopamine varied from 25% in cells that lacked spare receptors for dopamine to 90% in cells with receptor reserve. These results, together with previous studies demonstrating partial agonist activity at serotonin 5-hydroxytryptamine (5-HT)1A receptors and antagonist activity at 5-HT2A receptors, support the identification of aripiprazole as a dopamine-serotonin system stabilizer. The receptor activity profile may underlie the unique activity of aripiprazole in animals and its antipsychotic activity in humans. [Abstract]

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2

I am not sure if the original post will read this or not, since the post was made in 2006, however, we do appreciate all the great information you posted for future site users.

Thank you.

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3

i think i got tremors and symtoms of parkinsons from abilify

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4

Abilify is awful! This drug has done more damage to me in 5 months than my mental disorder ever has. I also have movement disorders and Abilify has caused another one! These doctors know nothing about this drug

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