https://rxchat.com/Discuss/lyrica-and-subutex-276093_s2.htm?utm_source=forums_posts&utm_medium=RSS&utm_campaign=RSS can Lyrica and subutex be used at the same time - Filed in Lyrica en-us Copyright 2026 RxChat.com. All Rights Reserved. Fri, 31 Oct 2014 16:28:36 GMT 60 https://rxchat.com/images/mc_logo.png https://rxchat.com/Discuss/lyrica-and-subutex-276093_s2.htm?utm_source=forums_posts&utm_medium=RSS&utm_campaign=RSS https://rxchat.com/Discuss/lyrica-and-subutex-276093_s2.htm?utm_source=forums_posts&utm_medium=RSS&utm_campaign=RSS#r_387143 https://rxchat.com/Discuss/lyrica-and-subutex-276093_s2.htm?utm_source=forums_posts&utm_medium=RSS&utm_campaign=RSS#r_387143 @kb39, <br/> <br/> From what I've seen posted on various drug interaction checkers, apparently using <a href="https://rxchat.com/Drugs/Subutex/" target="_blank">Subutex</a> (<a href="https://rxchat.com/Drugs/Buprenorphine/" target="_blank">buprenorphine</a>) with <a href="https://rxchat.com/Drugs/Lyrica/" target="_blank">Lyrica</a> (<a href="https://rxchat.com/Drugs/Pregabalin/" target="_blank">pregabalin</a>) can increase your risk of central nervous system <a href="https://rxchat.com/Categories/Antidepressant/" target="_blank">depression</a>; potentially leading to serious side effects that could be fatal. <br/> <br/> With that said, you may need to discuss this in more detail with your doctor as well, to ensure that frequent monitoring is done during your time on these medications. This way they can better determine whether or not you require an adjustment in your dosage in order to safely continue using both medications at the same time. <br/> <br/> I hope this helps! Fri, 31 Oct 2014 16:28:36 GMT