https://rxchat.com/Discuss/lisinopril-and-aleve-312144_s2.htm?utm_source=forums_posts&utm_medium=RSS&utm_campaign=RSS Is it ok to take these two meds together? Any major side effects from this combination? - Filed in Lisinopril en-us Copyright 2026 RxChat.com. All Rights Reserved. Sun, 27 Nov 2016 01:21:35 GMT 60 https://rxchat.com/images/mc_logo.png https://rxchat.com/Discuss/lisinopril-and-aleve-312144_s2.htm?utm_source=forums_posts&utm_medium=RSS&utm_campaign=RSS https://rxchat.com/Discuss/lisinopril-and-aleve-312144_s2.htm?utm_source=forums_posts&utm_medium=RSS&utm_campaign=RSS#r_531710 https://rxchat.com/Discuss/lisinopril-and-aleve-312144_s2.htm?utm_source=forums_posts&utm_medium=RSS&utm_campaign=RSS#r_531710 Hello, Karen! How are you? <br/> <br/> They should not be taken together, without your doctor's approval. <br/> <br/> According to the FDA listed interactions, <a href="https://rxchat.com/Drugs/Aleve/" target="_blank">Aleve</a> can reduce the efficacy of <a href="https://rxchat.com/Drugs/Lisinopril/" target="_blank">Lisinopril</a> and combining them could also affect kidney function. <br/> <br/> Additionally, NSAIDs are not always safe for people with high <a href="https://rxchat.com/Categories/Blood-Pressure/" target="_blank">blood pressure</a>/cardiac conditions, due to the fact that they can elevate <a href="https://rxchat.com/Categories/Blood-Pressure/" target="_blank">blood pressure</a> and cause fluid retention. <br/> <br/> Is there anything else I can help with? Sun, 27 Nov 2016 01:21:35 GMT