Has anyone had side effects from Vitrase? ## I personally don't have any experience with this medication, but I did find a list of notable side effects and allergic reactions that you can view below... Medication guidelines note that one should seek medical attention if any of these severe allergic reactions occur while taking Vitrase: rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue Other less serious side effects may include: pain, itching, redness, or swelling where the medication was injected. Please post back if you have any other questions or comments to add.