Can Symproic be used for other colon problems besides that which is related to opioid use? I don't take opioids but do have terrible bowel problems. I was given a sample but am leery and learned that the script is $375.00 for 30... Any discounts or samples available? Sounds like the epi pen deal. Sad! Thanks. ## Are there any other uses for Symproic? And why is it so expensive? ## Of no help. Do you know much about it since it's so new? ## It is most commonly used to treat opiate related constipation, according to FDA approval, it contains the active ingredient Naldemidine. Its typical side effects may include nausea, dizziness, diarrhea, stomach pain, and abdominal cramping. Overall, it really depends on what is causing your issues, and what type of issues you are experiencing....