On Oxaliplatin for four cycles still have the cold reactions and was wanting to find out how long it stays in your body? ## How long does it take to get Oxaliplatin and xeloda out of your system? ## Oxaliplatin has a short elimination half-life of about 10-25 minutes. Many pharmacists consider most or all of the drug to be out your system in the period of about 5 half-lives. In relation to this drug, that would mean Oxaliplatin takes roughly 2 hours to leave your system. Xeloda (Capecitabine) is largely eliminated as metabolites (> 95% of the dose). The terminal half-life of the parent drug and its metabolites is short (less than 1 hour), and excretion proceeds via the urine. Essentially this would mean that Xeloda should be out of your system for the most part within a 4-5 hour tim...