Can Orencia possibly cause chest pain and shortness of breath? ## It sounds like you may be having an allergic reaction to this drug or COPD: "Allergic reactions can happen on the day of treatment or the day after receiving ORENCIA. Tell your doctor or get emergency medical help right away if you have hives, swollen face, eyelids, lips, tongue, throat or trouble breathing." [1] I would suggest letting your doctor know ASAP. Do you have any other questions or information to add? Please post back if you do... References: [1] ## My husband just started on Orencia. Does anyone know how long before it helps reduce inflammation? Side effects? Etc.