Left ear infection. Instilled 3 drops Neomycin and Polymyxin 8 Sulfates and Hydrocortisone Otic in suspension tonight. I forgot to shake it. Can that hurt my ear? ## Not really, it just means that you may not have gotten the right amount of the active ingredients in those drops. Thus, from now on, you do need to be careful to make sure to shake it, as instructed. Doing that too many times could cause the infection to not be properly eradicated. You should, however, double check this information with your doctor or pharmacist. Is there anything else I can help with?