I have been prescribed Minivelle 0.05mg/24 hr transdermal patches along with Prometrium 100 mg. Has anyone else taken this combination and found relief from other menopausal symptoms such as hot flashes, trouble sleeping, outbursts of tears or rage? Also, will it cause weight gain or loss? Any other symptoms I should be aware of? ## Hello, Ti! How are you? I'm sorry about the symptoms you're having. Minivelle is an estrogen supplement, while Prometrium is a a progesterone supplement, as classified by the FDA, they are used to help with hormonal imbalances and to alleviate the symptoms of perimenopause and menopause. Typical side effects are listed as possibly including nausea, headache, irritability, skin irritation and mood swings. A woman typical produces both hormones each mo...

I recently visited my OB/GYN with concerns about adverse reactions due to stopping Loestrin24. My husband and I are trying to conceive, and to remedy my intense headaches, severe cramping, and heavy menstuation my doctor gave me a 3-week sample of Minivelle. Everything I have read states this drug is used during menopause. Why, then, has my doctor chose this for me at 25 while trying to conceive? ## Even the manufacturer's webpage directly states that Minivelle (estradiol transdermal system) is a prescription medicine patch that contains estradiol (an estrogen hormone), used to treat moderate to severe hot flashes due to menopause. That said, I too wonder why your doctor would have prescribed it for fertility reasons. Did he/she check your hormonal levels to see if you were ever low...