please explain Naltrexone can have markedly different pharmacokinetics at ultra low doses which may include the attenuation of a pre-established opioid the prevention of tolerance from the oxycodone in the formulation, and the possible amplification of oxycodone ## Think of it as wiping the slate clean. Thats what naltrexone does to the opiod receptors thereby "erasing" tolerance and making the receptors more sensitive again ## @John, I don't know if you may be looking for a second opinion on this, but I think the previous post does a good job of putting into perspective how Naltrexone works to prevent the tolerance of opioids. According to the U.S. National Library of Medicine, a 100mg dose of Naltrexone is said to provide a 96% blockade by the time 24 hours have passed, an...