I have a patient on a trial with it, and now she has hypercalcemia. Could this be due to the med or do I have to investigate other causes. I cannot tell her or her specialist, otherwise I risk wrecking the double blinding. But doing nothing may delay diagnosis of something ominous. any advice? ## I'm sorry, but I haven't been able to find this as a side effect by either the FDA, or the manufacturer. The typical ones are listed as possibly including headache, back ache, and fatigue. Is the patient on any other medications?

I have had HES for 12 years and want to trial Mepolizumab. My specialist has been unable to get me on a trial. What avenues do I have? ## It is really entirely up to the criteria set by the testing agencies and manufacturer, if they don't think you fit the patient profile, then they have the right to refuse you from their clinical trials and, unfortunately, you have no recourse in most countries. It's not the same as if someone were denying you a treatment options that has actually been proven to be life-sustaining. What reason did they give for not letting you into the trials? ## Thanks for your reply Verwon. In a nutshell, I didn't qualify for the trial because my death is not imminent. I have some control using hydroxyurea although the side effects depress all blood cell ...