Has anybody heard anything firsthand on this med? Is it safe? What is mechanism of action? Any info would be helpful. My doctor and I are hard at work on my weight! He believes there is a metabolic issue at hand also. I just think it's plain old livin' large. Need help to make changes. ## Hello, Based on my research, Lorcaserin is a weight-loss drug developed by Arena Pharmaceuticals. It has serotonergic properties and acts as an anorectic. On 22 December 2009 a New Drug Application (NDA) was submitted to the Food and Drug Administration (FDA) in the United States. On 16 September 2010, an FDA advisory panel voted to recommend against approval of the drug based on concerns over both safety and efficacy. Locaserin is used in conjunction with diet and exercise to help treat obesit...