https://rxchat.com/Discuss/Hydrocodone-Apap-5-325-Liver-damage-215342_s2.htm?utm_source=forums_posts&utm_medium=RSS&utm_campaign=RSS I take one and a half to two Hydrocodone Apap 5/325 a day and want to know if it's liver-damaging, esp the tylenol if I take it long-term to forever. I take it in the late afternoon. Then at bedtime I have to take (for a sleep disturbance) a clonazepam, .5 mg. Is this safe to continue in these dosages? - Filed in Hydrocodone en-us Copyright 2026 RxChat.com. All Rights Reserved. Fri, 18 Mar 2011 17:41:18 GMT 60 https://rxchat.com/images/mc_logo.png https://rxchat.com/Discuss/Hydrocodone-Apap-5-325-Liver-damage-215342_s2.htm?utm_source=forums_posts&utm_medium=RSS&utm_campaign=RSS https://rxchat.com/Discuss/Hydrocodone-Apap-5-325-Liver-damage-215342_s2.htm?utm_source=forums_posts&utm_medium=RSS&utm_campaign=RSS#r_183449 https://rxchat.com/Discuss/Hydrocodone-Apap-5-325-Liver-damage-215342_s2.htm?utm_source=forums_posts&utm_medium=RSS&utm_campaign=RSS#r_183449 Almost all medications are processed through the liver and yes, with long-term use, there is always the risk of damage to the liver or other organs from nonsteroidal <a href="https://rxchat.com/Categories/Anti-Inflammatory/" target="_blank">anti-inflammatory</a> medications, such as the <a href="https://rxchat.com/Drugs/Acetaminophen/" target="_blank">Acetaminophen</a> in this. <br/> <br/> Many people, however, take more than one and a half, to two of the <a href="https://rxchat.com/Drugs/Hydrocodone/" target="_blank">Hydrocodone</a> with <a href="https://rxchat.com/Drugs/Acetaminophen/" target="_blank">Acetaminophen</a> in a day, so you are taking a very low amount. <br/> <br/> <br/> <a href="https://rxchat.com/wiki/Vicodin/" target="_blank" rel="nofollow">https:/&#173;/&#173;rxchat.com/&#173;wiki/&#173;Vicodin/&#173;</a> <br/> <br/> <br/> Long-term use of the <a href="https://rxchat.com/Drugs/Clonazepam/" target="_blank">Clonazepam</a> has been know to cause some problems, such as sexual dysfunction, <a href="https://rxchat.com/Categories/Antidepressant/" target="_blank">depression</a> and cognitive impairment, but they are not known to be permanent, for most people they usually wear off about 6 months after they stop taking it. <br/> <br/> <br/> <a href="https://rxchat.com/wiki/Clonazepam/" target="_blank" rel="nofollow">https:/&#173;/&#173;rxchat.com/&#173;wiki/&#173;Clonazepam/&#173;</a> <br/> <br/> Are there any other questions or comments? Fri, 18 Mar 2011 17:41:18 GMT