My aunt was taken to the hospital and the doctor in the emergency room stopped her perphenazine/amitriptyline after taking it for 30 years. Now she is in a state that doctors cannot understand. Did the stopping of her meds cause this? ## Yes, both Perphenazine and Amitriptyline are medications that work on brain chemicals and stopping them abruptly may result in both withdrawal and rebound effects, which could put her in a very bad state. What types of symptoms is she experiencing?