I find that when I use ibuprofen, tylenol, aspirin or triaminic -d that I get a patch of discoloration of my cheeks. It varies, most of the time seems to have a purplish undertone. Please advise if there is anyone out there with the same experience /advise. ## A rash is a known side effect of Ibuprofen, and Aspirin, as it is with many others, according to FDA reports. Other side effects may include nausea, dizziness, headache, and increased risk of bleeding. Another possibility is that you may have rosacea, which is known to be aggravated by some medications, including those that can dilate blood vessels, and/or cause blood thinning. Have you consulted a doctor? It would be best to have this checked out, to be sure what's causing it, and what your treatment options might be.