Does amox tr-k have any potency left after 6 years? ## Hello, Barc! How are you? It's very doubtful, especially if it is in one of the bottles that pharmacies use, because even in the original factory sealed bottle, the maximum shelf-life of most pills is only 4 or 5 years. Taking an expired antibiotic is also not a good idea, since it creates the risk of your developing antibiotic resistant bacteria. The FDA lists the typical antibiotic side effects as possibly including nausea, dizziness, headache, non-allergic skin rash and diarrhea. Is there anything else I can help with?