My Dr. just changed my prescription of Anagrelide HCL 1 MG to one capsule to 3 times a day, what are the appropriate times I should be taking them. I normally go to bed around 10pm. ## Hello, Rita! How are you? Unless the prescription specifics that it's to be taken every 8 hours, that usually means morning, noon and evening. Such as when you wake up, at lunchtime and at bed time, but it's always best to double check with your doctor to be sure.' The FDA lists the typical side effects of this medication as possibly including nausea, headache, diarrhea, fatigue and weakness. Is there anything else I can help with?

I've been taking hydroxyurea for E.T for 8yrs. now. Would vinpocetine be of any help? Also, what about pregnenoline? ## Hello, Charles! How are you? I'm sorry about your condition. Both of these are just considered supplements in the U.S. The FDA has not approved them for any medical use. According to some research articles, Vinpocetine is said to have cerebral blood-flow enhancing effects. Pregnenolone is a steroid hormone and while I'm seeing various benefits claimed for it, such as being neuroprotective, I've not seen anything about it helping with these types of blood issues. Have you consulted your doctor? There might not be any harm in trying them, but only your doctor can say with any certainty. ## Thank you for your thoughts.